Abstract
Mononeuritis multiplex and acute demyelinating polyneuropathy (Guillain-Bard syndrome) are well known in systemic lupus erythematosus (SLE). Chronic acquired demyelinating polyneuropathy has been reported rarely in SLE. Two young women had monophasic progressive limb weakness, areflexia, elevated CSF protein, and slow nerve conduction velocities as the first manifestation of SLE. Sural nerve biopsy in one patient revealed mild loss of myelinated fibers and an increased number of thinly myelinated fibres Steroid therapy led to improvement in both patients. These patients demonstrate that chronic demyelinating poly-neuropathy can be an unusual presentation of SLE, even preceding characteristic systemic disease by months.
- © 1984 by the American Academy of Neurology
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