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January 01, 1986; 36 (1) Articles

Decreased cerebral blood flow precedes multi‐infarct dementia, but follows senile dementia of Alzheimer type

Robert L. Rogers, John S. Meyer, Karl F. Mortel, Roderick K. Mahurin, Brian W. Judd
First published January 1, 1986, DOI: https://doi.org/10.1212/WNL.36.1.1
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Abstract

A 7-year prospective study among 181 neurologically normal elderly volunteers (mean age, 70.6 years) revealed an incidence of 3.3%, or 0.47% new cases per year, for Alzheimer's disease (SDAT) and 5.5%, or 0.78% new cases per year, for multi-infarct dementia (MID). The unusually high incidence of MID is considered to reflect preselection of a large percentage of volunteers (48.6%) with risk factors for (but without symptoms of) atherothrombotic stroke. Of 88 volunteers at risk of stroke, 11.4% developed MID within 7 years. In MID patients, cerebral blood flow (CBF) values began to decline around 2 years before onset of symptoms, while in SDAT patients, CBF levels remained normal until symptoms of dementia appeared; thereafter, CBF declined rapidly.

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