Share

May 09, 2017; 88 (19) Article

Body composition status and the risk of migraine

A meta-analysis

Bizu Gelaye, Simona Sacco, Wendy J. Brown, Haley L. Nitchie, Raffaele Ornello, B. Lee Peterlin
First published April 12, 2017, DOI: https://doi.org/10.1212/WNL.0000000000003919
Full PDF
Citation
Permissions

Make Comment

See Comments

Downloads
218

Share

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective: To evaluate the association between migraine and body composition status as estimated based on body mass index and WHO physical status categories.

Methods: Systematic electronic database searches were conducted for relevant studies. Two independent reviewers performed data extraction and quality appraisal. Odds ratios (OR) and confidence intervals (CI) were pooled using a random effects model. Significant values, weighted effect sizes, and tests of homogeneity of variance were calculated.

Results: A total of 12 studies, encompassing data from 288,981 unique participants, were included. The age- and sex-adjusted pooled risk of migraine in those with obesity was increased by 27% compared with those of normal weight (odds ratio [OR] 1.27; 95% confidence interval [CI] 1.16–1.37, p < 0.001) and remained increased after multivariate adjustments. Although the age- and sex-adjusted pooled migraine risk was increased in overweight individuals (OR 1.08; 95% CI 1.04, 1.12, p < 0.001), significance was lost after multivariate adjustments. The age- and sex-adjusted pooled risk of migraine in underweight individuals was marginally increased by 13% compared with those of normal weight (OR 1.13; 95% CI 1.02, 1.24, p < 0.001) and remained increased after multivariate adjustments.

Conclusions: The current body of evidence shows that the risk of migraine is increased in obese and underweight individuals. Studies are needed to confirm whether interventions that modify obesity status decrease the risk of migraine.

GLOSSARY

BMI=
body mass index;
CI=
confidence interval;
HUNT-2=
second Health Survey of Nord-Trondelag County;
ICHD=
International Classification of Headache Disorders;
IL=
interleukin;
NOS=
Newcastle-Ottawa Scale;
OR=
odds ratio

Footnotes

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Supplemental data at Neurology.org

  • Received October 28, 2016.
  • Accepted in final form February 14, 2017.
View Full Text

AAN Non-Member Subscribers

Purchase access

Letters: Rapid online correspondence

  • Author response to Dr. Gupta
    • Bizu Gelaye, PhD, Harvard T. H. Chan School of Public Health
    • Simona Sacco, MD, Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila
    • Wendy Brown, PhD, University of Queensland, School of Human Movement and Nutrition Sciences (Brisbane, Australia)
    • Haley Nitchie, BS, Johns Hopkins University School of Medicine, Department of Neurology (Baltimore, MD)
    • Raffaele Ornello, MD, Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L’Aquila
    • B. Lee Peterlin, DO, Lancaster General Health (Lancaster, PA)
    Submitted September 10, 2018
  • Vagaries of meta-analysis: Migraine attacks increase with high and low BMI
    • Vinod K. Gupta, Physician, Medical Director, Gupta Medical Center
    Submitted April 29, 2018
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. [email protected]
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
Advertisement

Topics Discussed

Alert Me

Recommended articles