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April 03, 2018; 90 (14) Editorial

Vascular disease and cerebral amyloid deposition

Oscar L. Lopez, Pauline Maillard
First published March 16, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005242
Oscar L. Lopez
From the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and Department of Neurology (P.M.), University of California, Davis.
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Pauline Maillard
From the Department of Neurology (O.L.L.), University of Pittsburgh, PA; and Department of Neurology (P.M.), University of California, Davis.
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Vascular disease and cerebral amyloid deposition
Oscar L. Lopez, Pauline Maillard
Neurology Apr 2018, 90 (14) 635-636; DOI: 10.1212/WNL.0000000000005242

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This article has a correction. Please see:

  • Vascular disease and cerebral amyloid deposition - August 14, 2018
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The study reported by Hughes et al.1 has important implications for understanding the relationship between clinical and subclinical systemic vascular disease and in vivo cerebral β-amyloid (Aβ) deposition and brain structure. The authors found that markers of central arterial stiffness were associated with Aβ deposition (heart-carotid pulse wave velocity [PWV]), lower brain volumes (carotid-femoral PWV), and white matter hyperintensities (WMH) (carotid-femoral PWV) in elderly individuals without dementia. In addition, the combination of the high burden of WMH and Aβ positivity was associated with carotid-femoral PWV. These findings confirmed previous observations on the relationship between arterial stiffness and Aβ deposition, and consolidated the notion that there is an association between systemic vascular disease and Aβ deposition.2–5 In addition, as noted here, these associations occurred in Caucasians as well as in African Americans.

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  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.

  • See page 645

  • © 2018 American Academy of Neurology
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