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July 10, 2018; 91 (2 Supplement 1) ArticleOpen Access

The biology of cutaneous neurofibromas

Consensus recommendations for setting research priorities

Jean-Philippe Brosseau, Dominique C. Pichard, Eric H. Legius, Pierre Wolkenstein, Robert M. Lavker, Jaishri O. Blakeley, Vincent M. Riccardi, Sharad K. Verma, Isaac Brownell, Lu Q. Le
First published July 9, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005788
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  • Figure 1
    Figure 1 Clinical cutaneous neurofibroma examples across body regions

    Cutaneous neurofibromas can develop on hair-bearing skin (A) or non-hair-bearing skin on the palm (B) or sole (C) (arrows).

  • Figure 2
    Figure 2 Paracrine signaling working model in neurofibroma

    Schwann cells, which depend on the nerve and heregulin (HRG) to proliferate, secrete stem cell factor (SCF). SCF binds to the receptor kit on mast cell, which in turn stimulates collagen deposition through activation of fibroblast by the transforming growth factor–β (TGF-β).

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