Article Figures & Data
Figures
- Figure 1 Polymorphism of cutaneous neurofibromas (cNF) in a single patient
Many different aspects of cNF can be seen in this patient, including sessile cNF (arrows), globular cNF (arrowheads), and pedunculated cNF (asterisks). NF = neurofibromas.
- Figure 2 Proposed categories of clinically observed cutaneous neurofibromas (cNF) to be considered in the prospective validation study
(A) Nascent/latent cNF. (B) Flat cNF. (C) Sessile cNF. (D) Globular cNF. (E) Pedunculated cNF.
- Figure 3 Cutaneous neurofibromas (cNF), morphologic aspect
The lesion is made of scattered spindle cells (arrowheads) that correspond to Schwann cells and fibroblasts, admixed with numerous capillaries and veins (asterisks) and mast cells (arrows) (hematoxylin and eosin, ×400, and inset ×25).
- Figure 4 Histopathologic features of cutaneous neurofibromas (cNF)
cNF in which various cell types are evidenced using immunostainings. (A, B) Hematoxylin & eosin at 25 and 200 magnification show a cNF presenting as a self-limiting tumor in the skin with no peripheral capsule and in which numerous spindle cells are seen. (C–G) Immunostainings developed with DAB with antibodies to CD117 (C, ×200), S100 protein (D ×25 and E ×100), and CD34 (F ×25 and G ×100). These stains demonstrate numerous mast cells showing strong membrane expression of CD117 (C), Schwann cells displaying heterogeneous cytoplasmic and nuclear expression of S100 protein (D, E), and CD34+ fibroblasts (F,G).
- Figure 5 Unified clinicopathologic aspects of neurofibromas
(A) Clinical pictures show the various subtypes of cutaneous neurofibromas (cNF). This includes digital photographs of nascent (visible by ultrasound, but not the naked eye), flat, sessile, globular, and pedunculated cNF. The ultrasound image is courtesy of Dominique Pichard. The red arrow tip indicates the cNF involving the epidermis and dermis. (B) Gross and histologic pictures show the various NF subtypes involving skin and subcutaneous tissue (diffuse, with or without atypia). The upper panels show a cutaneous and subcutaneous NF with diffuse growth pattern replacing the dermis (upper right picture) and the subcutaneous fat tissue (hematoxylin & eosin, ×25 and ×100). The middle panels show a neurofibroma involving the dermis and subcutaneous tissue with 2 distinct growth patterns including plexiform (arrowheads) and diffuse (hematoxylin & eosin, ×25). The lower panels show a neurofibroma located entirely in the subcutaneous tissue with a plexiform neurofibroma with intraneural growth pattern (hematoxylin & eosin, ×100).
Tables
Disputes & Debates: Rapid online correspondence
NOTE: All contributors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.
- Stay timely. Submit only on articles published within the last 8 weeks.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- 200 words maximum.
- 5 references maximum. Reference 1 must be the article on which you are commenting.
- 5 authors maximum. Exception: replies can include all original authors of the article.
- Submitted comments are subject to editing and editor review prior to posting.