Table 2 Retrospective ACTH studies: Short-term results

Ref.nClassType of ACTH (dose)No. wk of full doseTotal Rx, wkOther Rx
* Discontinued because of side effects.
p < 0.002.
ACTH = adrenocorticotropic hormone; Rx = treatments; F/U = follow-up; SIS = symptomatic infantile spasm; CIS = cryptogenic infantile spasm; N = natural; NS = not stated; TS = tuberous sclerosis; S = synthetic; NR = not relevant; HPT = hypertension; CM = cardiomyopathy; CN = completely normal; alt = alternate days; Pneum = pneumonia.
2525IVN (110 IU)2.1NSNo
2622 TSIVN (20–140 IU) or S (0.2–1.2 mg)66NS
25 CISNSNSNS
119 SISNSNSNS
2726IVN (40–129 IU/m2)2–254.5–44NS
2830IVN (150 IU/m2)112NS
2955IVN (80 IU alt)26–14Yes
    Early, <1 mo31
    Late24
Mean F/U, moCessation of spasms, no. (%)SIS vs CIS, no. (%)Resolution of hypsarrhythmia, no. (%)Relapse, %Side effects, %D/C*
26.514 (67)8 (89) vs 10 (83)12 (57)4 (27)273
9816 (73)NRNS10 (62)HPT 45, CM 9
20 (80)NS6 (30)
71 (59)NS22 (31)
3617 (65)NR17 (65)2 (12)NSNS
2530 (100)NS29 (97) CN14 (47)NS
5341 (75)NSNS5 (9)Pneum 20
27 (87)
14 (58)