Table 2 Cox-proportional hazard model for the risk of dementia and dementia subtypes by fasting insulin groups: the Honolulu-Asia Aging Study

Insulin levelTotal dementia, n = 2,568AD, n = 2,472*VaD, n = 2,363
HR (95% CI)HR§ (95% CI)HR (95% CI)HR§ (95% CI)HR (95% CI)HR§ (95% CI)
Data are estimated hazard ratios (95% confidence interval) for the risk of dementia for the low and high groups compared to the medium group of fasting insulin level.
* The analyses excluded subjects with vascular dementia (VaD) and other types of dementia.
† The analyses excluded subjects with Alzheimer disease (AD) and other types of dementia.
‡ Model adjusted for age, education, and fasting glucose and ApoE ε4 status.
§ Model adjusted for age, education, fasting glucose, ApoE ε4 status, mid-life blood pressure, cholesterol, smoking status, and alcohol intake; % weight change from mid- to late-life, late-life depression, ankle brachial index, history of type II diabetes, stroke, and coronary heart disease.
Low (<7.2 mIU/dL)1.541.481.411.261.852.43
(1.11–2.11)(1.06–2.06)(0.92–2.16)(0.81–1.94)(0.90–3.84)(1.12–5.28)
Medium (7.2–23.0 mIU/dL)1.001.001.001.001.001.00
High (>23.0 mIU/dL)1.541.501.381.451.251.10
(1.05–2.26)(1.02–2.23)(0.84–2.90)(0.87–2.44)(0.50–3.12)(0.50–2.83)