Table 3 Cox proportional hazard model for the risk of dementia and dementia subtypes by logarithm levels of fasting insulin: the Honolulu-Asia Aging Study

Log-insulinTotal dementia, n = 2,568AD, n = 2,472*VaD, n = 2,363
HR (95% CI)HR§ (95% CI)HR (95% CI)HR§ (95% CI)HR (95% CI)HR§ (95% CI)
Data are estimated hazard ratios (95% confidence interval) for the risk of dementia associated with each increase of one logarithm unit of fasting insulin for values < and ≥ 3.1 (logarithm fasting insulin 3.1 = 22.2 mIU/L fasting insulin).
* The analyses excluded subjects with vascular dementia (VaD) and other types of dementia.
† The analyses excluded subjects with Alzheimer disease (AD) and other types of dementia.
‡ Model adjusted for age, education, fasting glucose, and ApoE ε4 status.
§ Model adjusted for age, education, fasting glucose, ApoE ε4 status, mid-life blood pressure, cholesterol level, smoking status, and alcohol intake; % weight change from mid- to late-life, late-life depression, ankle brachial index, history of type II diabetes, stroke, and coronary heart disease.
For values <3.10.760.800.710.800.700.51
(0.72–0.79)(0.78–0.83)(0.67–0.76)(0.75–0.86)(0.57–0.88)(0.40–0.65)
For values ≥3.11.641.621.461.411.881.35
(1.07–2.52)(1.05–2.48)(0.83–2.58)(0.81–2.45)(0.74–4.79)(0.60–3.61)