Teaching NeuroImage: Reinhold Hemimedullary Syndrome
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A 32-year-old man without vascular risk factors presented with acute onset vertigo, swallowing dysfunction, and right-sided weakness. Physical examination revealed the following signs on the left side: Horner syndrome; lower motor neuron 9th, 10th, and 12th cranial nerve palsies; cerebellar limb ataxia; loss of pain and temperature on the face; and loss of fine touch and proprioception on the face, trunk, and limbs. On the right side, he had hemiplegia with loss of pain and temperature on the trunk and limbs. Brain MRI revealed acute infarct involving the left half of the medulla (Figure, A and B). CT angiogram of the head and neck vessels showed occlusion of the left vertebral artery V4 segment (Figure, C, D, and E). A diagnosis of Reinhold complete hemimedullary syndrome was made (Table).1,-,3 The almost similar incomplete hemimedullary syndrome of Babinski-Nageotte lacks ipsilateral hypoglossal nerve palsy.2 Workup for stroke etiology revealed normal glycosylated hemoglobin, lipid profile, and negative hypercoagulable, autoimmune, and vasculitis panels. Echocardiogram was normal with prolonged cardiac telemetry revealing no cardiac arrhythmias. He was maintained on acetylsalicylic acid 100 mg once daily and atorvastatin 40 mg at nighttime for secondary stroke prophylaxis.
Noncontrast brain MRI showing hyperintense signal involving the left hemimedulla on diffusion-weighted imaging (A; black arrow) with corresponding hypointensity on apparent diffusion coefficient sequences (B; black arrow), suggestive of acute infarct. Coronal section of CT cerebral angiogram demonstrating nonvisualization of the left vertebral artery V4 segment (C; white arrow) and intact basilar artery flow distally (E; white arrow). Abrupt occlusion of the left vertebral artery V4 segment shown on the three-dimensional shaded surface display volume rendering (SS-VRT) reconstructed images (D; white arrow).
Description of the Medullary Vascular Syndromes
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Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
Submitted and externally peer reviewed. The handling editor was Whitley Aamodt, MD, MPH.
Teaching Slides links.lww.com/WNL/C515
- Received July 27, 2022.
- Accepted in final form October 27, 2022.
- © 2022 American Academy of Neurology
References
Letters: Rapid online correspondence
- Author Response: Teaching NeuroImage: Reinhold Hemimedullary Syndrome
- Praveen Kesav, Neurologist, Cleveland Clinic Abu Dhabi
Submitted April 16, 2023 - Reader Response: Teaching NeuroImage: Reinhold Hemimedullary Syndrome
- Yannick Béjot, Neurologist, University Hospital of Dijon, Dijon Stroke Registry, France
Submitted March 17, 2023
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