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April 11, 2023; 100 (15) Review

Microembolism and Other Links Between Migraine and Stroke

Clinical and Pathophysiologic Update

Simona Sacco, Andrea M. Harriott, Cenk Ayata, Raffaele Ornello, Rodrigo Bagur, Amado Jimenez-Ruiz, Luciano A. Sposato
First published December 15, 2022, DOI: https://doi.org/10.1212/WNL.0000000000201699
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Article Information

vol. 100 no. 15 716-726
DOI: 
https://doi.org/10.1212/WNL.0000000000201699
PubMed: 
36522158
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received June 13, 2022
  • Accepted in final form November 1, 2022
  • First Published December 15, 2022.

Article Versions

Copyright & Usage: 
© 2022 American Academy of Neurology

Author Disclosures

    1. Simona Sacco, MD,
    2. Andrea M. Harriott, MD, PhD,
    3. Cenk Ayata, MD, PhD,
    4. Raffaele Ornello, MD, PhD,
    5. Rodrigo Bagur, MD,
    6. Amado Jimenez-Ruiz, MD and
    7. Luciano A. Sposato, MD, MBA, FRCPC
  1. Simona Sacco, MD,
    2. Scientific Advisory Boards:

    1. Simona Sacco reports personal fees as speaker or advisor from Abbott, Allergan-Abbvie, AstraZeneca, Eli Lilly, Lundbeck, Novartis, NovoNordisk, Pfizer, Teva; research grants from Allergan, Novartis, Uriach; fees for CME/education from Medscape, Neurodiem Ology Medical Education; compensation as chief section editor for the section Headache and Neurogenic Pain in Frontiers of Neurology.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. non-financial support from Abbott, Allergan, Bayer, Bristol-Myers Squibb, Daiichi-Sankyo, Eli Lilly, Lundbeck, Medtronic, Novartis, Pfizer, Starmed, Teva.

    Editorial Boards:

    1. 2011-2015 Editorial Advisory Panel, Clinical Science2012-2016 Visiting Editor, The Journal of Headache and Pain2012-2020 Editorial Board, European Neurology2015-2020 Editorial Board, StrokeFrom 2016, Editorial Board, European Stroke JournalFrom 2017 Associate Editor, The Journal of Headache and Pain2018-2020 Review Editor in Stroke, Frontiers in NeurologyFrom 2018 Advisory Board, Neurological SciencesFrom 2018 Editorial Board, International Journal of Stroke2018-2020 Academic Editor, PLOS ONEFrom 2020 Assistant Editor, Stroke2020 Co-editor, The Journal of Headache and PainFrom 2020 Associate Editor in Stroke, Frontiers in NeurologyFrom 2021 Specialty Chief Editor in Headache and Pain Medicine, Frontiers in From 2022 member of the Editorial Board of Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Novartis, Allergan, Uriach

    Research Support, Government Entities:

    1. Italian Ministry of Health Multi-center Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS). A collaborative study from the Italian Stroke Organization (ISO) Basic Science network (Prot. 2017CY3J3W)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Andrea M. Harriott, MD, PhD,
    3. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Honoraria from Headache Cooperative of New England for lecture.

    Editorial Boards:

    1. (1) Cephalalgia, Associate Editor, 2017 - 2022(2) Cephalalgia Reports, Associate Editor, 2017 - 2022(3) eNeurologicalSci, Associate Editor, 2018 - 2022

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. Unpaid authorship agreement - Abbvie

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH-NINDS, K08NS124991

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Cenk Ayata, MD, PhD,
    4. Scientific Advisory Boards:

    1. (1) Omniox, Inc(2) Neurelis, Inc

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. (1) The Journal of Headache and Pain, Associate Editor, 2019-

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Bioaxone, Inc

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) Electrocore, Inc.(2) Hovid Berhad, research grant

    Research Support, Government Entities:

    1. (1) NIH

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Raffaele Ornello, MD, PhD,
    5. Scientific Advisory Boards:

    1. Eli Lilly

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Eli Lilly(2) Teva(3) Novartis

    Editorial Boards:

    1. (1) The Journal of Headache and Pain, Junior Editor, 2020-present(2) Frontiers in Neurology, Review Editor, 2021-2022(3) Frontiers in Neurology, Associate Editor, 2022-present(3) Brain Sciences, Topic Editor, 2020-2022

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Rodrigo Bagur, MD,
    6. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. Journal of the American Heart Association, Guest Associate Editor, 2021 to dateEuroIntervention, Section Editor, 2020 to date

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Commercial, Medtronic Canada, less than 5000/year.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Amado Jimenez-Ruiz, MD and
    7. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Luciano A. Sposato, MD, MBA, FRCPC
    8. Scientific Advisory Boards:

    1. Bayer Canada

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. (1) Boehringer Ingelheim (speaker honoraria), Pfizer, Kathleen & Dr Henry Barnett Chair in Stroke Research (Western University, London, Ontario, Canada)(2) Edward and Alma Saraydar Neurosciences Fund (London Health Sciences Foundation)(3) Pfizer INC.(4) Gore(5) Boehringer Ingelheim

    Editorial Boards:

    1. (1) Editorial board: Neurology.(2) Editorial board: Stroke Journal. Section editor for Neurocardiology.(3) Editorial board and Associate Editor: JAHA(4) Chair: Brain and Heart Task Force, World Stroke Organization

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Biotechnological and Applied Clinical Sciences (S.S., R.O.), University of L'Aquila, Italy; Neurovascular Research Laboratory (A.M.H., C.A.), Department of Radiology, Vascular Division (A.M.H., C.A.), and Headache and Neuropathic Pain Division (A.M.H.), Department of Neurology, Massachusetts General Hospital, Boston; Division of Cardiology (R.B.), Western University, London, Ontario, Canada; Department of Neurology (A.J.-R.), Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico; Departments of Clinical Neurological Sciences, Epidemiology and Biostatistics and Anatomy and Cell Biology (L.A.S.), Schulich School of Medicine and Dentistry, Heart & Brain Laboratory (L.A.S.), and Robarts Research Institute (L.A.S.), Western University; and Lawson Health Research Institute (L.A.S.), London, Ontario, Canada.
  1. Correspondence
    Dr. Sposato lucianosposato{at}gmail.com
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