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May 30, 2023; 100 (22) Research Article

Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology

Puja Agarwal, Sue E. Leurgans, Sonal Agrawal, Neelum T. Aggarwal, Laurel J. Cherian, Bryan D. James, Klodian Dhana, Lisa L. Barnes, David A. Bennett, Julie A. Schneider
First published March 8, 2023, DOI: https://doi.org/10.1212/WNL.0000000000207176
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Article Information

vol. 100 no. 22 e2259-e2268
DOI: 
https://doi.org/10.1212/WNL.0000000000207176
PubMed: 
36889921
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received September 1, 2022
  • Accepted in final form January 26, 2023
  • First Published March 8, 2023.

Article Versions

Copyright & Usage: 
© 2023 American Academy of Neurology

Author Disclosures

    1. Puja Agarwal, PhD,
    2. Sue E. Leurgans, PhD,
    3. Sonal Agrawal, PhD,
    4. Neelum T. Aggarwal, MD,
    5. Laurel J. Cherian, MD,
    6. Bryan D. James, PhD,
    7. Klodian Dhana, MD, PhD,
    8. Lisa L. Barnes, PhD,
    9. David A. Bennett, MD and
    10. Julie A. Schneider, MD
  1. Puja Agarwal, PhD,
    2. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Speaker Honoraria- Wake Forest Baptist Medical Center

    Editorial Boards:

    1. Associate editor Journal of Alzheimer's Disease

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIA; #R01AG062637; CoI ;(2) NIA; #R01AG054476; CoI

    Research Support, Academic Entities:

    1. Rush University; Cohn's Fellowship

    Research Support, Foundations and Societies:

    1. 1.Alzeimer's Association; #AARG-21-852512; 01/2022 – ;12/2023; PI;2. P30AG072975 developmental grant, 01/2022- 12/2022; PI

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Sue E. Leurgans, PhD,
    3. Scientific Advisory Boards:

    1. NIH R21 to David A. Gallo, University of Chicago. I serve on ;the DSMB

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. (1) Neurology, Associate Editor for Statistics, 2015-

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Neurovision: Protocol NVI-010, Statistician, 2019-present

    Research Support, Government Entities:

    1. (1)NIH: P30AG010161 (ADC), Core Leader and ;Statistician, 2007-present ;(2)NIH: R01AG042210, Statistician, 2011-2019 ;(3)NIH: P20MD006886, Statistician, 2013-2019;(4)NIH: U01AG046152, Statistician, 2015-2019;(5)NIH: R01AG015819, Statistician, 2015-2019;(6)NIH: R01AG033570, Statistician, 2015-2020;(7)NIH: R01AG047976, Statistician, 2015-present;(8)NIH: R01AG034374, Statistician, 2015-present ;(9)NIH: RF1AG051641, Statistician, 2016-present ;(10)NIH: R01AG054476, Statistician, 2016-present;(11)NIH: RF1AG054057, Statistician, 2016-present;(12)NIH: UH3NS100599, Statistician, 2016-present ;(13)NIH: R01AG054058, Statistician, 2017-present;(14)NIH: R01AG064233, Statistician, 2019-present;(15)NIH: R01AG061028, Statistician, 2019-present;(16)NIH: R01MH113425-03S1, Statistician, 2019-present;(17)NIH: R01AG062711, Statistician, 2021-present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Sonal Agrawal, PhD,
    4. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Neelum T. Aggarwal, MD,
    5. Scientific Advisory Boards:

    1. DSMB Preventing Alzheimer's Disease with Cognitive Training ;- R01AG058234;DSMB Intervention for Cognitive Reserve Enhancement in ;Delaying the onset of Alzheimer's symptom expression - ;R01AG054130

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. Honoraria-Course Presenter - Institute on Methods and ;Protocols for Advancement of Clinical Trials in ADRD ;(IMPACT-AD);;Honoraria-Course Presenter -Alzheimer's Association-;Interdisciplinary Summer Research Institute(AA-ISRI)

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1) Commercial Biogen Payment for Advisory Board Services - ;Digital Biomarkers

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Laurel J. Cherian, MD,
    6. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH, Co-Investigator, Diet Patterns and Alzheimer's Disease ;and Other Dementias, 1R01AG054476-01A1 R, 2016 to present;;NIH, Co-Investigator, MIND Diet and Dementia Prevention in ;Ischemic Stroke Patients, R01AG062637-YR01, 2021 to present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Bryan D. James, PhD,
    7. Scientific Advisory Boards:

    1. (1) Eisai inc.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. 1) American Journal of Epidemiology, Associate Editor for ;Social media, 2020-

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1) Alzheimer's Association

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) National Institute on Aging K01 AG050823, PI, 2015-2021;(2) National Institute on Aging R01 R01AG072559, PI, 2022-2027

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. (1) Vivid Genomics, Inc.

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Klodian Dhana, MD, PhD,
    8. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. British Journal of Nutrition, Editor, Current;;Journal of Alzheimer's Disease, Associate Editor, Current

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Institute on Aging, R21AG070287, Principal Investigator, 2020-2023;;Alzheimer's Association Research Grant, AARG 22 974154, Principal ;Investigator, 2023-2026

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Lisa L. Barnes, PhD,
    9. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. Journal of Aging And Health, member of editorial board, ;2006 - present.;Journal of Gerontology: Medical Sciences, 2021 - 2026;Alzheimer's & Dementia: Translational Research and Clinical ;Interventions, 2022, Senior Associate Editor;Alzheimer's & Dementia, Deputy Editor, 2023

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1)NIA, P30-AG10161, PI of Clinical Core, 9/30/91 – ;6/30/21;(2) R01AG052583, PI, 4/1/16-3/31/21;(3) NIA, RF1AG51641, Co-I 9/1/16-6/30/21;(4) NIA, R01AG060376, Co-I 9/15/18-6/30/23;(5) NIA, R01AG056405, PI 9/1/2018 - 5/31/2023;(6) NIA, R01AG51635, Co-I 6/1/16-5/31/21;(7) NIA, R01AG52583, Co-I 4/1/16-3/31/21;(8) NIA, RF1AG54057, Co-I 9/1/16-5/31/21;(9) NHLBI, NHHSN268201800010I-CC, 8/13/18-2/15/23;(10) NIA, R01AG061028, 3/15/19-11/30/23;(11) NHLBI, U01HL146245, 1/1/19-12/31/25;(12) NIA, R01AG055430, 7/15/17-4/30/22;(13) NIA, R01AG066134, 9/15/19-5/31/24

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. David A. Bennett, MD and
    10. Scientific Advisory Boards:

    1. (1) Scientific Advisory Boards Vigorous Minds, B4X, Inc;(3) EABs: MCSA; CCNA; CIMA-Q, WFU, ;Emory, MODEL-AD, REGARDS, ADD Health, Dunedin Study, MCSA, ;NAD ;RCMAR, MEMCARE, ASPREE, MRC UCL, REGARDS, DPUK, ;(4) DMCs: HRS, MIDUS;(5) National Advisory Council on Aging;(6) AbbVie Inc;(7) B4X Inc

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. No compensation for any;;(2) Current Alzheimer Research, Editorial Board;;(3) Neuroepidemiology, Editorial Board;(4) Journal of the Prevention of Alzheimer's Disease, ;Editorial Board;(5) Journal of Alzheimer's Disese;(5) Journal of Alzheimer's Disease, Editorial Board;(6) Alzheimer's & Dementia: Translational Research & ;Clinical Interventions, Editorial Board

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant, Origent Data Sciences NIH SBIR grant;AbbVie DSMB, B4X Inc

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Neurovision - amyloid eye imaging

    Research Support, Government Entities:

    1. NIH: P30AG72975, PI; P30AG72975, Co-I; R01AG15819, PI; ;R01AG17917, PI; R01AG36042, MPI; R01AG54058, PI; U01AG61356, ;MPI; R01AG52476, MPI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Julie A. Schneider, MD
    11. Scientific Advisory Boards:

    1. (1) Invited Member, International Research Grant Program ;(IRGP) Council., Alzheimer's Association ;(2) Scientific Advisory Board, Fondation Plan Alzheimer, ;France ;(3) Scientific Advisory Board of the Dutch CAA Foundation ;(4) Scientific External Advisory ;Board, University of Washington/Group Health Alzheimer's ;Disease Patient Registry/Adult Changes in Thought study.– ;Principal Investigator: Dr. Eric Larson External Advisory ;Board ;(5) New York University – Alzheimer's Disease Core ;Center (2/2017 – Invited Chair of External Advisory ;Committee);(6) Scientific Advisor, AVID radiopharmaceuticals ;(division of Eli Lilly) ;(7)Scientific Advisor, Alnylam ;(8) External Advisory Boards for Kansas Alzheimer's disease ;Center ;(9) External Advisory for Boston Alzheimer's disease ;(10) External Advisory for University of California, ;Irvine. ;(11) OSMB, Discovery Research group, Mass General ;(12) OSMB, Framingham Heart Study, ;(13) Invited Member, National Advisory ;Council on Aging (NACA);(14) Scientific advisory board, Apellis pharmaceuticals;(15) Consultant, Cerveau Technologies;(16) Consultant, Takeda

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. 2013-current; Editorial Board, Journal of Neuropathology ;and Experimental Neurology.;2017 - current; Lancet Neurology;2019 - current; Editorial Board, Cerebral Circulation - ;Cognition & Behavior;2020-2021 - Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) AVID radiopharmaceuticals (Lilly);(2) Alnylam;(3) National Hockey League;(4) Apellis;(5) Cerveau Technologies;(6) Takeda

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. National Hockey League

  1. From the Rush Alzheimer's Disease Center (P.A., S.E.L., N.A., B.D.J., L.L.B., D.A.B., J.A.S.), Departments of Internal Medicine (P.A., B.D.J., K.D.), Clinical Nutrition (P.A.), Neurological Sciences (S.E.L., N.T.A., L.J.C., L.L.B., D.A.B., J.A.S.) and Pathology (S.A., J.A.S.); and Rush Institute of Healthy Aging (K.D.), Rush University Medical Center, Chicago, IL.
  1. Correspondence
    Dr. Agarwal puja_agarwal{at}rush.edu
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