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February 21, 2023; 100 (8) Research Article

Longitudinal Changes in Blood Biomarkers of Clinical Alzheimer Disease in a Biracial Population Sample

Kumar B. Rajan, Elizabeth A. McAninch, Neelum T. Aggarwal, Lisa L. Barnes, Robert S. Wilson, Jennifer Weuve, Charles S. DeCarli, Denis A. Evans
First published November 29, 2022, DOI: https://doi.org/10.1212/WNL.0000000000201289
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Article Information

vol. 100 no. 8 e874-e883
DOI: 
https://doi.org/10.1212/WNL.0000000000201289
PubMed: 
36446595
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received December 22, 2020
  • Accepted in final form August 10, 2022
  • First Published November 29, 2022.

Article Versions

Copyright & Usage: 
© 2022 American Academy of Neurology

Author Disclosures

    1. Kumar B. Rajan, PhD,
    2. Elizabeth A. McAninch, MD,
    3. Neelum T. Aggarwal, MD,
    4. Lisa L. Barnes, PhD,
    5. Robert S. Wilson,
    6. Jennifer Weuve, ScD,
    7. Charles S. DeCarli, MD and
    8. Denis A. Evans, MD
  1. Kumar B. Rajan, PhD,
    2. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Adjunct Professor, University of California at DavisProfessor, Rush University Medical Center

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH grants - R01AG051635 (principal investigator, 2016-2021), RF1AG057532 (principal investigator, 2017-2021), R01AG058679 (principal investigator, 2019-2024), R01AG073627 (principal investigator, 2021-2026)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National Institutes of Health (R01AG051635, RF1AG057532, R01AG058679, R01AG073627).

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Elizabeth A. McAninch, MD,
    3. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. Editorial Board Membership2018-present Clinical Diabetes and Endocrinology2022-present Clinical Thyroidology

    Patents:

    1. Patent Pending: US20210361921A1. Hypothyroidism treatment.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant for Abbvie (I have not received any money yet, but technically I'm starting to consult for them)

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Neelum T. Aggarwal, MD,
    4. Scientific Advisory Boards:

    1. DSMB Preventing Alzheimer's Disease with Cognitive Training - R01AG058234DSMB Intervention for Cognitive Reserve Enhancement in Delaying the onset of Alzheimer's symptom expression - R01AG054130

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1) Commercial Biogen Payment for Advisory Board Services - Digital Biomarkers

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Lisa L. Barnes, PhD,
    5. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. Journal of Aging And Health, member of editorial board, 2006 - present.Journal of Gerontology: Medical Sciences, 2021 - 2026Alzheimer's & Dementia: Translational Research and Clinical Interventions, 2022, Senior Associate Editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1)NIA, P30-AG10161, PI of Clinical Core, 9/30/91 – 6/30/21(2) R01AG052583, PI, 4/1/16-3/31/21(3) NIA, RF1AG51641, Co-I 9/1/16-6/30/21(4) NIA, R01AG060376, Co-I 9/15/18-6/30/23(5) NIA, R01AG056405, PI 9/1/2018 - 5/31/2023(6) NIA, R01AG51635, Co-I 6/1/16-5/31/21(7) NIA, R01AG52583, Co-I 4/1/16-3/31/21(8) NIA, RF1AG54057, Co-I 9/1/16-5/31/21(9) NHLBI, NHHSN268201800010I-CC, 8/13/18-2/15/23(10) NIA, R01AG061028, 3/15/19-11/30/23(11) NHLBI, U01HL146245, 1/1/19-12/31/25(12) NIA, R01AG055430, 7/15/17-4/30/22(13) NIA, R01AG066134, 9/15/19-5/31/24

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Robert S. Wilson,
    6. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. (1) Aging, Neuropsychology, and Cognition, Consulting Editor, 2004-present;(2) Psychology and Aging, Consulting Editor, 2007-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH/NIA R01AG17917, Co-I, 2001-2014;(2) NIH/NIA P30AG10161, Co-I, 1991-2014;(3) NIH/NIA R01AG34374, Co-I, 2008-2014;(4) NIH/NIA R01AG15819, Co-I, 1998-2014.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Jennifer Weuve, ScD,
    7. Scientific Advisory Boards:

    1. (1) Milken Institute School of Public Health, George Washington University. External Advisory Board member for NIH-NIEHS/R01 ES029509 (PI: Power)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. (1) Epidemiology, Editorial Board member, 2016-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Alzheimer's Association(2) Health Effects Institute

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH-NIA, R01 AG073179, CoI, 2021-2024(2) NIH-NIA, U19 AG066567-01A1, CoI, 2021-2026(3) NIH-NINDS, R01 NS119651, CoI, 2021-2026(4) NIH-NIA, P01 AG036694, CoI, 2020-2025(5) NIH-NIA, R01AG067497, MPI, 2020-2025(6) NIH-NIA, R01AG065359, PI, 2020-2024(7) NIH-NINDS, U54 NS115266, CoI, 2020-2025(8) NIH-NIA, R13 AG064971, PI, 2019-2024(9) NIH-NIEHS, R01 ES028694, CoI, 2018-2022(10) NIH-NIA, R01 AG062348, CoI, 2018-2023(11) NIH-NIA, RF1 AG057532, CoI, 2017-2021(12) NIH-NIA, R01 AG051635, CoI, 2016-2021(13) NIH-NIEHS, R01 ES024749, CoI, 2015-2020

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Charles S. DeCarli, MD and
    8. Scientific Advisory Boards:

    1. 1) Novartis Pharmaceuticals2) Eisai Pharmaceuticals3) Nova Nordisk

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. 1)Novartis Pharmaceuticals

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. National Institutes of Health

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Denis A. Evans, MD
    9. Scientific Advisory Boards:

    1. None

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. None

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Principal Investigator or Co-Investigator of NIH grantsAG11101, AG030146

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. None

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Rush Institute for Healthy Aging (K.R., D.E.), Rush University Medical Center, Chicago IL; Stanford University (E.A.M.), Palo Alto, CA; Rush Alzheimer's Disease Center (N.A., L.L.B., R.W.), Chicago IL; Boston University (J.W.), Boston, MA; and Department of Neurology (C.S.D.), University of California, Davis.
  1. Correspondence
    Dr. Rajan kbrajan{at}ucdavis.edu
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Article usage

Article usage: November 2022 to February 2023

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Nov 202220203Highwire
Dec 2022465018Highwire
Jan 202313004Highwire
Feb 2023258444129Highwire

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