Abstract
Coagulation defects and/or clinical bleeding in neonates have been documented in the world literature in more than 30 infants born to mothers receiving anticonvulsant drugs. In this study, phenobarbital was shown to reduce vitamin K-dependent clotting factors on a dose-related basis in animals. Phenobarbital at 10 mg per kilogram in cats reduced the vitamin K-dependent clotting factor VII by 50 percent, whereas phenobarbital at 40 mg per kilogram reduced both factors II and VII by 85 percent. Vitamin K given with the anticonvulsant drug corrected the depression of the coagulation factors. Kittens born to cats receiving phenobarbital. showed reduction of clotting factors.
- © 1974 by the American Academy of Neurology
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