Abstract
Extensor digitorum longus end-plate ultrastructure was quantitatively analyzed in rats fed 300 ppm acrylamide in their diet for 10 to 90 days and in control animals. After 20 days of treatment the mean nerve terminal area was markedly enlarged due to distention by neurofilaments. Subsequently more than half of all nerve terminals disappeared, leaving behind denuded or Schwann-cell-covered postsynaptic regions. Denervation of the end-plates was subtotal; at least one nerve terminal persisted at each junction. Nerve terminals surviving after 30 days had a normal mean size and a reduced content of mitochondria and synaptic vesicles. Postsynaptic atrophy developed only after the presynaptic abnormalities were fully established. After cessation of treatment nerve terminals returned to the end-plates within 30 days but the synaptic vesicle and mitochondrial content of the terminals remained depressed even after 60 days of recovery.
- © 1974 by the American Academy of Neurology
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
