Abstract
Early treatment with thyrotropin-releasing hormone (TRH) at high doses improves neurologic recovery from experimental spinal injury in cats. We have now compared the effects of TRH dose and time of treatment on neurologic outcome. TRH-treated animals showed better motor recovery than saline controls; effects were dose-related (between 0.02 mg/kg/hr and 2.0 mg/kg/hr), with significant effects even at the lowest dose. Cats treated at 24 hours after injury also improved significantly. These findings provide additional support for TRH trials in human spinal injury and suggest that even late treatment may be effective.
- © 1984 by the American Academy of Neurology
Disputes & Debates: Rapid online correspondence
NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.
- Stay timely. Submit only on articles published within the last 8 weeks.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- 200 words maximum.
- 5 references maximum. Reference 1 must be the article on which you are commenting.
- 5 authors maximum. Exception: replies can include all original authors of the article.
- Submitted comments are subject to editing and editor review prior to posting.