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May 01, 1985; 35 (5) Brief Communication

Chronic agonist therapy for Parkinson's disease

A 5‐year study of bromocriptine and pergolide

Christopher G. Goetz, Caroline M. Tanner, Russell H. Glantz, Harold L. Klawans
First published May 1, 1985, DOI: https://doi.org/10.1212/WNL.35.5.749
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Abstract

We used pergolide to treat 10 patients with idiopathic Parkinson's disease who had first responded to, and then failed, bromocriptine therapy. At the end of 5 years, patients had improved when compared with study entry. Peak efficacy, equal with both drugs, was seen at 12 months. After a mean treatment of 29 months, bromocriptine was no longer effective, but pergolide was still beneficial.

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