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March 01, 1988; 38 (3) Brief Communications

Protein redistribution diet restores motor function in patients with dopa‐resistant “off” periods

Jonathan H. Pincus, Kathryn Barry
First published March 1, 1988, DOI: https://doi.org/10.1212/WNL.38.3.481
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Abstract

Sixteen parkinsonians with acquired drug-resistant "off" periods without dyskinesia were placed on a diet in which virtually all protein was concentrated in the evening meal. Restoration of sensitivity to levodopa resulted in 88%. Ten patients (62%) have continued to comply with the diet for 7 months (mean). Two patients were studied in detail. Immobility correlated with elevated plasma levels of large neutral amino acids (LNAA), normality with low LNAA.

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