Clinical Trials and Future Research

• Diagnostic criteria in clinical trials

  Michael H. Brooke

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• Natural history of ALSSymptoms, strength, pulmonary function, and disability

  Benjamin Rix Brooks

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• Development of measurement techniques

  Theodore L. Munsat

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• Clinical trials of riluzole in patients with ALS

  R. G. Miller, J. P. Bouchard, P. Duquette, A. Eisen, D. Gelinas, Y. Harati, T. L. Munsat, L. Powe, J. Rothstein, P. Salzman, R. L. Sufit

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• Recombinant human insulin-like growth factor-I in ALSDescription of a double-blind, placebo-controlled study

  D. J. Lange, K. J. Felice, B. W. Festoff, M. J. Gawel, D. F. Gelinas, R. Kratz, E. C. Lai, M. F. Murphy, H. M. Natter, F. H. Norris, S. Rudnicki

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• Issues in clinical trial design IUse of natural history controls. A protagonist view

  Theodore L. Munsat

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• Issues in clinical trial design IUse of natural history controls. An antagonist view

  Robert L. Sufit

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• Issues in clinical trial design IISelection of end point measures

  Mark B. Bromberg, Benjamin R. Brooks

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• Drug combination treatment in patients with ALSCurrent status and future directions

  Hiroshi Mitsumoto, Richard K. Olney

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• Advances in ALS Workshop SummaryResearch and future goals

  Michael H. Brooke, Michael J. Strong

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