April 01, 1997; 48 (Suppl 5) Articles
Neuromuscular junction physiology in myasthenia gravis
Isoforms of the acetylcholine receptor in extraocular muscle and the contribution of sodium channels to the safety factor
Henry J. Kaminski, Jose I. Suarez, Robert L. Ruff
First published April 1, 1997, DOI: https://doi.org/10.1212/WNL.48.Suppl_5.8S
Henry J. Kaminski
MD
Jose I. Suarez
MD
Robert L. Ruff
MD, PhD
Neuromuscular junction physiology in myasthenia gravis
Isoforms of the acetylcholine receptor in extraocular muscle and the contribution of sodium channels to the safety factor
Henry J. Kaminski, Jose I. Suarez, Robert L. Ruff
Neurology Apr 1997, 48 (Suppl 5) 8S-17S; DOI: 10.1212/WNL.48.Suppl_5.8S
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vol. 48 no. Suppl 5 8S-17S
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History:
- First Published April 1, 1997.
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Copyright 1997 by Advanstar Communications Inc.
Author Disclosures
- Henry J. Kaminski, MD,
- Jose I. Suarez, MD and
- Robert L. Ruff, MD, PhD
- Henry J. Kaminski, MD,
- Jose I. Suarez, MD and
- Robert L. Ruff, MD, PhD
- From the Departments of Neurology (Drs. Kaminski and Ruff) and Neuroscience (Dr. Suarez), Case Western Reserve University School of Medicine, Cleveland Veterans Affairs Medical Center, University Hospitals of Cleveland, Cleveland, OH.
- This work was supported by the Office of Research and Development, Medical Research Service of the Department of Veterans Affairs (Drs. Kaminski and Ruff). Dr. Kaminski was also supported by a National Institutes of Health grant (EY-00332). Dr. Ruff was also supported by the Muscular Dystrophy Association.
- Address correspondence and reprint requests to Dr. Robert L. Ruff, Neurology Service 127(W), Cleveland VAMC, 10701 East Blvd., Cleveland, OH 44106.
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- Article
- Abstract
- Nerve terminals release the transmitter acetylcholine.
- Postsynaptic membrane specializations.
- Nerve-muscle signaling.
- The safety factor for neuromuscular transmission.
- AChR structure.
- AChR subunits.
- Location of the agonist-binding sites on the AChR.
- Differences between the adult- and fetal-type AChR.
- AChR isoforms in multi-innervated muscle fibers.
- Mechanisms of ion passage.
- Microstructure of AChR subunits.
- Arrangement of the segments within a subunit.
- Naturally occurring mutations affect AChR performance.
- Summary.
- REFERENCES
- Figures & Data
- Info & Disclosures
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