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June 13, 2000; 54 (11) Brief Communications

Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factor

H. Openshaw, O. Stuve, J.P. Antel, R. Nash, B.T. Lund, L.P. Weiner, A. Kashyap, P. McSweeney, S. Forman
First published June 13, 2000, DOI: https://doi.org/10.1212/WNL.54.11.2147
H. Openshaw
From the Department of Neurology (Dr. Openshaw) and Division of Hematology and Bone Marrow Transplantation (Drs. Kashyap and Forman)City of Hope National Medical Center, Duarte, CA; the Departments of Neurology (Dr. Stuve) and Medical Oncology (Drs. Nash and McSweeney), Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle; the Neuroimmunology Unit (Dr. Antel), Montreal Neurological Institute, McGill University, Montreal, Canada; and the Department of Neurology (Drs. Lund and Weiner), University of Southern California School of Medicine, Los Angeles.
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O. Stuve
From the Department of Neurology (Dr. Openshaw) and Division of Hematology and Bone Marrow Transplantation (Drs. Kashyap and Forman)City of Hope National Medical Center, Duarte, CA; the Departments of Neurology (Dr. Stuve) and Medical Oncology (Drs. Nash and McSweeney), Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle; the Neuroimmunology Unit (Dr. Antel), Montreal Neurological Institute, McGill University, Montreal, Canada; and the Department of Neurology (Drs. Lund and Weiner), University of Southern California School of Medicine, Los Angeles.
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J.P. Antel
From the Department of Neurology (Dr. Openshaw) and Division of Hematology and Bone Marrow Transplantation (Drs. Kashyap and Forman)City of Hope National Medical Center, Duarte, CA; the Departments of Neurology (Dr. Stuve) and Medical Oncology (Drs. Nash and McSweeney), Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle; the Neuroimmunology Unit (Dr. Antel), Montreal Neurological Institute, McGill University, Montreal, Canada; and the Department of Neurology (Drs. Lund and Weiner), University of Southern California School of Medicine, Los Angeles.
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R. Nash
From the Department of Neurology (Dr. Openshaw) and Division of Hematology and Bone Marrow Transplantation (Drs. Kashyap and Forman)City of Hope National Medical Center, Duarte, CA; the Departments of Neurology (Dr. Stuve) and Medical Oncology (Drs. Nash and McSweeney), Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle; the Neuroimmunology Unit (Dr. Antel), Montreal Neurological Institute, McGill University, Montreal, Canada; and the Department of Neurology (Drs. Lund and Weiner), University of Southern California School of Medicine, Los Angeles.
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B.T. Lund
From the Department of Neurology (Dr. Openshaw) and Division of Hematology and Bone Marrow Transplantation (Drs. Kashyap and Forman)City of Hope National Medical Center, Duarte, CA; the Departments of Neurology (Dr. Stuve) and Medical Oncology (Drs. Nash and McSweeney), Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle; the Neuroimmunology Unit (Dr. Antel), Montreal Neurological Institute, McGill University, Montreal, Canada; and the Department of Neurology (Drs. Lund and Weiner), University of Southern California School of Medicine, Los Angeles.
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L.P. Weiner
From the Department of Neurology (Dr. Openshaw) and Division of Hematology and Bone Marrow Transplantation (Drs. Kashyap and Forman)City of Hope National Medical Center, Duarte, CA; the Departments of Neurology (Dr. Stuve) and Medical Oncology (Drs. Nash and McSweeney), Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle; the Neuroimmunology Unit (Dr. Antel), Montreal Neurological Institute, McGill University, Montreal, Canada; and the Department of Neurology (Drs. Lund and Weiner), University of Southern California School of Medicine, Los Angeles.
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A. Kashyap
From the Department of Neurology (Dr. Openshaw) and Division of Hematology and Bone Marrow Transplantation (Drs. Kashyap and Forman)City of Hope National Medical Center, Duarte, CA; the Departments of Neurology (Dr. Stuve) and Medical Oncology (Drs. Nash and McSweeney), Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle; the Neuroimmunology Unit (Dr. Antel), Montreal Neurological Institute, McGill University, Montreal, Canada; and the Department of Neurology (Drs. Lund and Weiner), University of Southern California School of Medicine, Los Angeles.
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P. McSweeney
From the Department of Neurology (Dr. Openshaw) and Division of Hematology and Bone Marrow Transplantation (Drs. Kashyap and Forman)City of Hope National Medical Center, Duarte, CA; the Departments of Neurology (Dr. Stuve) and Medical Oncology (Drs. Nash and McSweeney), Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle; the Neuroimmunology Unit (Dr. Antel), Montreal Neurological Institute, McGill University, Montreal, Canada; and the Department of Neurology (Drs. Lund and Weiner), University of Southern California School of Medicine, Los Angeles.
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S. Forman
From the Department of Neurology (Dr. Openshaw) and Division of Hematology and Bone Marrow Transplantation (Drs. Kashyap and Forman)City of Hope National Medical Center, Duarte, CA; the Departments of Neurology (Dr. Stuve) and Medical Oncology (Drs. Nash and McSweeney), Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle; the Neuroimmunology Unit (Dr. Antel), Montreal Neurological Institute, McGill University, Montreal, Canada; and the Department of Neurology (Drs. Lund and Weiner), University of Southern California School of Medicine, Los Angeles.
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Full PDF
Citation
Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factor
H. Openshaw, O. Stuve, J.P. Antel, R. Nash, B.T. Lund, L.P. Weiner, A. Kashyap, P. McSweeney, S. Forman
Neurology Jun 2000, 54 (11) 2147-2150; DOI: 10.1212/WNL.54.11.2147

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Abstract

Article abstract Four of 10 patients who were enrolled on protocols of high-dose immunosuppression with peripheral blood stem cell rescue for MS experienced neurologic worsening while receiving recombinant human granulocyte colony-stimulating factor. There was improvement when methylprednisolone was given to three of the patients, but one patient died of respiratory failure. The mechanism of the neurologic worsening is uncertain.

  • Received January 20, 2000.
  • Accepted in final form February 10, 2000.
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