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May 09, 2000; 54 (9) Brief Communications

Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study

M.C. Walter, H. Lochmüller, P. Reilich, T. Klopstock, R. Huber, M. Hartard, M. Hennig, D. Pongratz, W. Müller–Felber
First published May 9, 2000, DOI: https://doi.org/10.1212/WNL.54.9.1848
M.C. Walter
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H. Lochmüller
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Citation
Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study
M.C. Walter, H. Lochmüller, P. Reilich, T. Klopstock, R. Huber, M. Hartard, M. Hennig, D. Pongratz, W. Müller–Felber
Neurology May 2000, 54 (9) 1848-1850; DOI: 10.1212/WNL.54.9.1848

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Abstract

Article abstract The authors assessed the safety and efficacy of creatine monohydrate (Cr) in various types of muscular dystrophies in a double-blind, crossover trial. Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 patients with Becker dystrophy, 8 patients with Duchenne dystrophy, and 6 patients with sarcoglycan-deficient limb girdle muscular dystrophy) were randomized to receive Cr or placebo for 8 weeks. There was mild but significant improvement in muscle strength and daily-life activities by Medical Research Council scales and the Neuromuscular Symptom Score. Cr was well tolerated throughout the study period.

  • Received August 6, 1999.
  • Accepted January 18, 2000.
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