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February 27, 2001; 56 (4) Articles

Quality of life in ALS is maintained as physical function declines

R.A. Robbins, Z. Simmons, B.A. Bremer, S.M. Walsh, S. Fischer
First published February 27, 2001, DOI: https://doi.org/10.1212/WNL.56.4.442
R.A. Robbins
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Z. Simmons
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B.A. Bremer
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S.M. Walsh
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Citation
Quality of life in ALS is maintained as physical function declines
R.A. Robbins, Z. Simmons, B.A. Bremer, S.M. Walsh, S. Fischer
Neurology Feb 2001, 56 (4) 442-444; DOI: 10.1212/WNL.56.4.442

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Abstract

Objectives: To study patients with ALS to determine how physical function, quality of life (QOL), and spirituality or religiousness change over time, and what relationship these changes have to one another.

Methods: Sixty patients with ALS were studied prospectively. They were assessed at baseline, 3 months, and 6 months, using questionnaires designed to measure general quality of life (McGill Quality of Life questionnaire), religiosity (Idler Index of Religiosity), ALS-specific health-related quality of life (SIP/ALS-19), and ALS-specific function (ALS functional rating scale).

Results: A two-way repeated measures multivariate analysis of variance revealed that both the passage of time and the specific QOL scales used were factors in predicting patient quality of life (F[1, 59]= 9.87, p < 0.003 and F[3, 177]= 16.90, p < 0.001) Despite a progressive decline in physical function as measured by the ALS-specific function score, the general QOL and religiosity scores changed little. In contrast, the ALS-specific health-related QOL score declined in parallel with the ALS-specific function score.

Conclusions: QOL in patients with ALS appears to be independent of physical function, which agrees with a previous cross-sectional study. The ALS-specific health-related QOL score is primarily a measure of physical function. QOL instruments that assess spiritual, religious, and psychological factors produce different results than those obtained using measures of physical function alone.

  • Received July 10, 2000.
  • Accepted October 27, 2000.
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