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Frontotemporal dementia (FTD) has become recognized as a common cause of progressive cognitive and behavioral decline in adults. Estimates indicate that as many as 20% of adults presenting to a memory disorders clinic with impaired language, cognition, and behavior may suffer from FTD. This supplement summarizes a meeting concerned with FTD and Pick’s disease held in Philadelphia in May 1999. Attendees included scientists from cognitive, biochemical, and molecular perspectives involved in the study of patients with FTD, as well as caregivers of patients with FTD. The purpose of this meeting was to develop a multidisciplinary approach to the diagnosis and treatment of FTD. Our goal was to propel scientific investigations and management strategies forward in a manner that is sensitive to and informed by the clinical, biochemical, and molecular features of this disorder.
Patients with FTD are generally younger than individuals with AD, but this demographic feature is not sufficient to distinguish FTD from AD. Routine neuropsychologic investigations have not discriminated between FTD and AD with any reliability because both FTD and AD patients have difficulty with executive functions such …
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