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Creatine is a guanidino compound produced endogenously by the liver and consumed in diets inclusive of meat and fish. Creatine monohydrate (CM) supplementation increases lean body mass, high-intensity power output, and strength in young healthy volunteers.1 Clinical trials of CM supplementation have demonstrated modest improvements in muscular strength, endurance, and activities of daily living (ADL) for patients with neuromuscular disorders.2-4⇓⇓ We evaluated the potential benefits of short-term CM supplementation for patients with hereditary motor sensory neuropathy (HMSN) type I and II.
Methods.
Subjects.
Thirty-nine subjects (mean age 42.5 years) with HMSN types I (n = 34) and II (n = 5) gave their informed consent to take part. The diagnosis of HMSN I or II was confirmed from the clinical presentation, family history, as well as confirmatory genetic or electrophysiologic assessment.
Study design.
A double-blinded, placebo-controlled, crossover design was used. Subjects were randomized to CM or placebo for 1 month, followed by a 5-week washout period. They then …
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