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May 14, 2002; 58 (9) Correspondence

Clinical features of withdrawal headache following overuse of triptans and other headache drugs

Alexander Mauskop
First published May 14, 2002, DOI: https://doi.org/10.1212/WNL.58.9.1443
Alexander Mauskop
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Clinical features of withdrawal headache following overuse of triptans and other headache drugs
Alexander Mauskop
Neurology May 2002, 58 (9) 1443-1444; DOI: 10.1212/WNL.58.9.1443

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To the Editor:

I commend Katsarava et al.1 for undertaking the difficult task of a prospective study that involved hospitalizing a large number of patients, and for producing an incredible long-term success rate of 97%. However, I wish the authors had taken the extra step of double-blinding the trial. My concern is that their report describes clinical features of a condition that may not exist. Although withdrawal from caffeine has been shown to cause headaches in a double-blind experiment,2 the existence of withdrawal or rebound headaches due to daily use of a simple analgesic, ergotamine, or a triptan has never been demonstrated scientifically. It may be that a number of anecdotal reports have created a myth of headache from medication overuse that is not supported by …

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