Articles

• Unmet medical needs in Parkinson’s disease

  William C. Koller, Winona Tse

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• New developments in levodopa therapy

  Peter A. LeWitt, Dag Nyholm

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• The origin of motor fluctuations in Parkinson’s diseaseImportance of dopaminergic innervation and basal ganglia circuits

  J. A. Obeso, M. Rodriguez-Oroz, C. Marin, F. Alonso, I. Zamarbide, J. L. Lanciego, M. Rodriguez-Diaz

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• The role of COMT inhibition in the treatment of Parkinson’s disease

  Werner Poewe

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• Safety and tolerability of COMT inhibitors

  David J. Brooks

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• Avoidance of dyskinesiaPreclinical evidence for continuous dopaminergic stimulation

  Peter Jenner

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• Continuous dopaminergic stimulation in early and advanced Parkinson’s disease

  Fabrizio Stocchi, C. Warren Olanow

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• Levodopa/carbidopa/entacapone (Stalevo)

  Robert A. Hauser

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• COMT inhibitors in Parkinson’s diseaseCan they prevent and/or reverse levodopa-induced motor complications?

  C. Warren Olanow, Fabrizio Stocchi

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