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Abstract
The authors studied the association of an exon 4 (E4*ε2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*ε2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers (p = 0.009). There was no association in men. Alleles ε3 or ε4 and promoter polymorphisms were not associated with disease course or severity.
- Received May 30, 2003.
- Accepted October 31, 2003.
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- Reply to Zwemmer et al
- Association of APOE polymorphisms with disease severity in MS is limited to women
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