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September 28, 2004; 63 (6) Brief Communications

Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy

F. Zimprich, R. Sunder-Plassmann, E. Stogmann, A. Gleiss, A. Dal-Bianco, A. Zimprich, S. Plumer, C. Baumgartner, C. Mannhalter
First published September 27, 2004, DOI: https://doi.org/10.1212/01.WNL.0000141021.42763.F6
F. Zimprich
From the Department of Clinical Neurology (Drs. F. Zimprich, Stogmann, A. Zimprich, and Baumgartner, and A. Dal-Bianco), Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Diagnostics (Drs. Sunder-Plassmann and Mannhalter, and S. Plumer), and Section of Clinical Biometrics, Department of Medical Computer Sciences (Dr. Gleiss), Medical University of Vienna, Austria.
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R. Sunder-Plassmann
From the Department of Clinical Neurology (Drs. F. Zimprich, Stogmann, A. Zimprich, and Baumgartner, and A. Dal-Bianco), Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Diagnostics (Drs. Sunder-Plassmann and Mannhalter, and S. Plumer), and Section of Clinical Biometrics, Department of Medical Computer Sciences (Dr. Gleiss), Medical University of Vienna, Austria.
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E. Stogmann
From the Department of Clinical Neurology (Drs. F. Zimprich, Stogmann, A. Zimprich, and Baumgartner, and A. Dal-Bianco), Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Diagnostics (Drs. Sunder-Plassmann and Mannhalter, and S. Plumer), and Section of Clinical Biometrics, Department of Medical Computer Sciences (Dr. Gleiss), Medical University of Vienna, Austria.
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A. Gleiss
From the Department of Clinical Neurology (Drs. F. Zimprich, Stogmann, A. Zimprich, and Baumgartner, and A. Dal-Bianco), Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Diagnostics (Drs. Sunder-Plassmann and Mannhalter, and S. Plumer), and Section of Clinical Biometrics, Department of Medical Computer Sciences (Dr. Gleiss), Medical University of Vienna, Austria.
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A. Dal-Bianco
From the Department of Clinical Neurology (Drs. F. Zimprich, Stogmann, A. Zimprich, and Baumgartner, and A. Dal-Bianco), Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Diagnostics (Drs. Sunder-Plassmann and Mannhalter, and S. Plumer), and Section of Clinical Biometrics, Department of Medical Computer Sciences (Dr. Gleiss), Medical University of Vienna, Austria.
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A. Zimprich
From the Department of Clinical Neurology (Drs. F. Zimprich, Stogmann, A. Zimprich, and Baumgartner, and A. Dal-Bianco), Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Diagnostics (Drs. Sunder-Plassmann and Mannhalter, and S. Plumer), and Section of Clinical Biometrics, Department of Medical Computer Sciences (Dr. Gleiss), Medical University of Vienna, Austria.
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S. Plumer
From the Department of Clinical Neurology (Drs. F. Zimprich, Stogmann, A. Zimprich, and Baumgartner, and A. Dal-Bianco), Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Diagnostics (Drs. Sunder-Plassmann and Mannhalter, and S. Plumer), and Section of Clinical Biometrics, Department of Medical Computer Sciences (Dr. Gleiss), Medical University of Vienna, Austria.
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C. Baumgartner
From the Department of Clinical Neurology (Drs. F. Zimprich, Stogmann, A. Zimprich, and Baumgartner, and A. Dal-Bianco), Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Diagnostics (Drs. Sunder-Plassmann and Mannhalter, and S. Plumer), and Section of Clinical Biometrics, Department of Medical Computer Sciences (Dr. Gleiss), Medical University of Vienna, Austria.
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C. Mannhalter
From the Department of Clinical Neurology (Drs. F. Zimprich, Stogmann, A. Zimprich, and Baumgartner, and A. Dal-Bianco), Clinical Institute of Medical and Chemical Laboratory Diagnostics, Division of Molecular Diagnostics (Drs. Sunder-Plassmann and Mannhalter, and S. Plumer), and Section of Clinical Biometrics, Department of Medical Computer Sciences (Dr. Gleiss), Medical University of Vienna, Austria.
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Full PDF
Citation
Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy
F. Zimprich, R. Sunder-Plassmann, E. Stogmann, A. Gleiss, A. Dal-Bianco, A. Zimprich, S. Plumer, C. Baumgartner, C. Mannhalter
Neurology Sep 2004, 63 (6) 1087-1089; DOI: 10.1212/01.WNL.0000141021.42763.F6

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Abstract

The multidrug transporter P-glycoprotein is suspected of contributing to pharmacoresistance in temporal lobe epilepsy (TLE). To assess the role of functional variations in its coding gene (ABCB1) the authors genotyped 210 patients with TLE who were stratified according to their degree of drug resistance. They identified a common haplotype that when present in the homozygous state significantly increased the risk for pharmacoresistance.

  • Received December 5, 2003.
  • Accepted in final form July 19, 2004.
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