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October 12, 2004; 63 (7) Articles

Incidence of parkinsonism and Parkinson disease in a general population

The Rotterdam Study

L. M.L. de Lau, P. C.L.M. Giesbergen, M. C. de Rijk, A. Hofman, P. J. Koudstaal, M. M.B. Breteler
First published October 11, 2004, DOI: https://doi.org/10.1212/01.WNL.0000140706.52798.BE
L. M.L. de Lau
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P. C.L.M. Giesbergen
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M. C. de Rijk
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A. Hofman
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P. J. Koudstaal
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M. M.B. Breteler
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Citation
Incidence of parkinsonism and Parkinson disease in a general population
L. M.L. de Lau, P. C.L.M. Giesbergen, M. C. de Rijk, A. Hofman, P. J. Koudstaal, M. M.B. Breteler
Neurology Oct 2004, 63 (7) 1240-1244; DOI: 10.1212/01.WNL.0000140706.52798.BE

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Abstract

Objective: To investigate the incidence of parkinsonism and Parkinson disease (PD) in the general population using in-person screening along with clinical data.

Methods: In the Rotterdam study, a prospective population-based cohort study of people aged ≥55 years, the authors assessed age- and sex-specific incidence rates of parkinsonism and PD among 6,839 participants who were free of parkinsonism at baseline. Case finding involved in-person screening at baseline and two follow-up visits, and additional information was obtained through continuous monitoring of the cohort by computer linkage to general practitioners’ and pharmacy records.

Results: After a mean follow-up period of 5.8 years, 132 subjects with incident parkinsonism were identified, of whom 67 (51%) had PD. The incidence of parkinsonism and PD increased with age, with incidence rates for PD increasing from 0.3 per 1000 person-years in subjects aged 55 to 65 years, to 4.4 per 1000 person-years for those aged ≥85 years. The overall age-adjusted incidence rate of any parkinsonism was not different in men and women, but men seem to have a higher risk for PD (male-to-female ratio, 1.54; 95% CI, 0.95 to 2.51).

Conclusion: Incidence rates for parkinsonism and Parkinson disease were higher than those reported by most previous studies, possibly because of the authors’ intensive case-finding methods involving in-person screening.

  • Received February 20, 2004.
  • Accepted May 26, 2004.
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