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It has been recognized for decades that the neuropathologic lesions of Alzheimer disease (AD) are not uncommon in normal aging.1 A challenge to this observation was that these studies may have included cognitively impaired individuals who escaped detection, thus contaminating the normal sample with mildly impaired persons. Recent focus on mild cognitive impairment (MCI) now identifies persons with defective memory but relatively normal activities of daily living and general cognitive function.2 Detecting individuals with MCI allows for their exclusion from normal samples, raising hopes for improved ability to predict who would and would not meet neuropathologic criteria for AD. The study by Bennett et al. in this issue,3 however, excluded both individuals with MCI and with dementia yet still finds that …
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