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January 24, 2006; 66 (1 suppl 1) Articles

The current status of treatment for inclusion-body myositis

Robert C. Griggs
First published December 16, 2005, DOI: https://doi.org/10.1212/01.wnl.0000192262.29924.9e
Robert C. Griggs
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The current status of treatment for inclusion-body myositis
Robert C. Griggs
Neurology Jan 2006, 66 (1 suppl 1) S30-S32; DOI: 10.1212/01.wnl.0000192262.29924.9e

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Abstract

There is no established treatment that improves, arrests, or slows the progression of inclusion-body myositis (IBM). Many anti-inflammatory, immunosuppressant, or immunomodulating agents have been administered to patients with IBM but the design of clinical trials was such that it can only be concluded that none produced rapid improvement. The natural history of the disease is for stabilization or improvement in a third of patients for 6 months or more. Thus some agents that did not produce dramatic benefit may have been prematurely abandoned. However, because high-dose prednisone worsens strength while decreasing inflammation but increases amyloid accumulation, alternative targets for intervention and novel treatment strategies are needed.

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  • Article
    • Abstract
    • Corticosteroids.
    • Cytotoxic drugs.
    • Immune-modulating therapy.
    • Beneficial responses to treatment in individual cases?
    • Treatments of possible benefit.
    • Responders vs non-responders: Possible subcategories of IBM.
    • Natural history of IBM and the design of randomized, controlled trials.
    • Implications of the natural history for past and future clinical trials.
    • Supportive care strategies.
    • Prospects for the future.
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