Primary progressive freezing gait: A syndrome with many causes
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Abstract
Primary progressive freezing gait (PPFG) is characterized by early gait freezing and a stereotyped progression. Of nine patients fol1owed up for 6 to 16 years, two were diagnosed pathologically: pallidonigroluysian degeneration (PNLD) and diffuse Lewy body disease. Four others evolved clinically into progressive supranuclear palsy and corticobasal degeneration. PPFG is not a distinct disorder but a syndrome with diverse causes. Long-term follow-up (≥10 years) and postmortem are required for accurate diagnosis. PNLD may be the primary form of disease.
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