Primary progressive freezing gait: A syndrome with many causes

Stewart A. Factor; Donald S. Higgins; Jiang Qian

doi:10.1212/01.wnl.0000196469.52995.ab

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Abstract

Primary progressive freezing gait (PPFG) is characterized by early gait freezing and a stereotyped progression. Of nine patients fol1owed up for 6 to 16 years, two were diagnosed pathologically: pallidonigroluysian degeneration (PNLD) and diffuse Lewy body disease. Four others evolved clinically into progressive supranuclear palsy and corticobasal degeneration. PPFG is not a distinct disorder but a syndrome with diverse causes. Long-term follow-up (≥10 years) and postmortem are required for accurate diagnosis. PNLD may be the primary form of disease.

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