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May 09, 2006; 66 (9) Articles

Prevalence and severity of microbleeds in a memory clinic setting

C. Cordonnier, W. M. van der Flier, J. D. Sluimer, D. Leys, F. Barkhof, P. Scheltens
First published May 8, 2006, DOI: https://doi.org/10.1212/01.wnl.0000210535.20297.ae
C. Cordonnier
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W. M. van der Flier
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J. D. Sluimer
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D. Leys
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F. Barkhof
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P. Scheltens
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Prevalence and severity of microbleeds in a memory clinic setting
C. Cordonnier, W. M. van der Flier, J. D. Sluimer, D. Leys, F. Barkhof, P. Scheltens
Neurology May 2006, 66 (9) 1356-1360; DOI: 10.1212/01.wnl.0000210535.20297.ae

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Abstract

Objective: To determine prevalence and severity of microbleeds (MBs) in a large cohort of patients attending a memory clinic.

Methods: The authors consecutively included patients attending their memory clinic between January 2002 and April 2005. They analyzed prevalence and number of MBs according to demographic, diagnostic, and MRI data.

Results: The authors included 772 patients (53% men, age 66 ± 11). One hundred twenty-seven patients (17%) exhibited at least one MB. The prevalence differed according to diagnostic groups (p < 0.0001): Sixty-five percent of patients with vascular dementia exhibited MBs vs 18% of Alzheimer disease patients, 20% of mild cognitive impairment patients, and 10% of patients with subjective complaints. The presence of MBs was associated with age, white matter hyperintensities, lacunar infarcts, and infarcts.

Conclusion: The prevalence of microbleeds (MBs) in a large cohort of patients attending a memory clinic is higher than previously described in community samples and lower than reported in stroke patients. This finding of a relatively high proportion of MBs in Alzheimer disease and mild cognitive impairment provides further evidence for the involvement of vascular factors in neurodegenerative diseases such as Alzheimer disease.

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Disputes & Debates: Rapid online correspondence

  • Prevalence and severity of microbleeds in a memory clinic setting
    • Joseph S Jeret, MD, FAAN, Mercy Medical Center, 220 Maple Ave, Rockville Centre, NY 11570BrainsRus2@aol.com
    Submitted July 17, 2006
  • Reply from the authors
    • Charlotte Cordonnier, Department of Neurology and Alzheimer center, Vrije Universteit Medical center, PO Box 7057, 1007 MB, Amsterdam, The Netherlandscharlotte.cordonnier2@wanadoo.fr
    • Wiesje M. van der Flier, Jasper D. Sluimer, Frederik Barkhof and Philip Scheltens
    Submitted July 17, 2006
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