This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Abrupt onset of hearing loss in chronic myelogenous leukemia has been reported. We report a patient in whom hearing loss and dizziness developed subacutely, and MRI revealed bilateral labyrinthine hemorrhage.
Case report.
A previously healthy 55-year-old woman experienced 6 weeks of fatigue and headache. She was treated with two courses of oral antibiotics for a presumed sinus infection without improvement. She then developed progressive left-sided hearing loss over 4 days followed by progressive right-sided hearing loss, resulting in complete bilateral deafness. The hearing loss was associated with increasing dizziness that prompted hospitalization. On admission she had a white blood cell count of 800,000/μL with myelocytes, promyelocytes, and mature neutrophilic predominance. The diagnosis of chronic myelogenous leukemia in chronic phase was confirmed by the cytogenetic studies and reverse transcription PCR specific for the BCR-ABL fusion transcript (confirming the presence of the Philadelphia chromosome [a t(9;22) translocation containing the BCR-AL fusion gene which encodes a 210-kd protein with deregulated tyrosine kinase …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Hemiplegic Migraine Associated With PRRT2 Variations A Clinical and Genetic Study
Dr. Robert Shapiro and Dr. Amynah Pradhan