Gradual hearing loss with bilateral labyrinthine hemorrhage in chronic myelogenous leukemia
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Abrupt onset of hearing loss in chronic myelogenous leukemia has been reported. We report a patient in whom hearing loss and dizziness developed subacutely, and MRI revealed bilateral labyrinthine hemorrhage.
Case report.
A previously healthy 55-year-old woman experienced 6 weeks of fatigue and headache. She was treated with two courses of oral antibiotics for a presumed sinus infection without improvement. She then developed progressive left-sided hearing loss over 4 days followed by progressive right-sided hearing loss, resulting in complete bilateral deafness. The hearing loss was associated with increasing dizziness that prompted hospitalization. On admission she had a white blood cell count of 800,000/μL with myelocytes, promyelocytes, and mature neutrophilic predominance. The diagnosis of chronic myelogenous leukemia in chronic phase was confirmed by the cytogenetic studies and reverse transcription PCR specific for the BCR-ABL fusion transcript (confirming the presence of the Philadelphia chromosome [a t(9;22) translocation containing the BCR-AL fusion gene which encodes a 210-kd protein with deregulated tyrosine kinase …
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