Neuroprotective agents for clinical trials in ALS
A systematic assessment
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Abstract
Background: Riluzole is currently the only Food and Drug Administration–approved treatment for ALS, but its effect on survival is modest.
Objective: To identify potential neuroprotective agents for testing in phase III clinical trials and to outline which data need to be collected for each drug.
Methods: The authors identified 113 compounds by inviting input from academic clinicians and researchers and via literature review to identify agents that have been tested in ALS animal models and in patients with ALS. The list was initially narrowed to 24 agents based on an evaluation of scientific rationale, toxicity, and efficacy in previous animal and human studies. These 24 drugs underwent more detailed pharmacologic evaluation.
Results: Twenty drugs were selected as suitable for further development as treatments for patients with ALS. Talampanel and tamoxifen have completed early phase II trials and have demonstrated preliminary efficacy. Other agents (ceftriaxone, minocycline, ONO-2506, and IGF-1 polypeptide) are already in phase III trials involving large numbers of patients with ALS. Remaining agents (AEOL 10150, arimoclomol, celastrol, coenzyme Q10, copaxone, IGF-1–viral delivery, memantine, NAALADase inhibitors, nimesulide, scriptaid, sodium phenylbutyrate, thalidomide, trehalose) require additional preclinical animal data, human toxicity and pharmacokinetic data including CNS penetration prior to proceeding to large scale phase III human testing. Further development of riluzole analogues should be considered.
Conclusions: Several potential neuroprotective compounds, representing a wide range of mechanisms, are available and merit further investigation in ALS.
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Letters: Rapid online correspondence
- Neuroprotective agents for clinical trials in ALS: A systematic assessment
- William J Burke, Saint Louis University, 3635 Vista at Grand; St. Louis, MOburkewj@slu.edu
Submitted September 20, 2006 - Reply from the Authors
- Bryan J. Traynor, SDGE, NIMH, Bld 35, Room 1A1014, 35 Convent Drive, Bethesda, MD 20892traynorb@mail.nih.gov
- Lucie Bruijn, Robin Conwit, Flint Beal, Gilmore O'Neill, Susan C. Fagan and Merit E. Cudkowicz
Submitted September 20, 2006
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