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September 12, 2006; 67 (5) Brief Communications

Occurrence of CNS demyelinating disease in patients with myasthenia gravis

Marc Gotkine, Yakov Fellig, Oded Abramsky
First published September 11, 2006, DOI: https://doi.org/10.1212/01.wnl.0000234142.41728.a0
Marc Gotkine
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Yakov Fellig
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Oded Abramsky
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Occurrence of CNS demyelinating disease in patients with myasthenia gravis
Marc Gotkine, Yakov Fellig, Oded Abramsky
Neurology Sep 2006, 67 (5) 881-883; DOI: 10.1212/01.wnl.0000234142.41728.a0

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Abstract

An increased incidence of multiple sclerosis (MS) has been reported in patients with myasthenia gravis (MG). We reviewed records of 214 patients with MG. CNS demyelinating disease (CNSDD) occurred in five patients (2.3%). CNSDD always occurred after the diagnosis of MG. Myelitis (including recurrent myelitis) was the most common CNS manifestation. All patients had antinuclear antibodies. CNSDD occurs more frequently in patients with MG and may be related to immune-modulating treatments including thymectomy.

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Letters: Rapid online correspondence

  • Occurrence of CNS demyelinating disease in patients with myasthenia gravis
    • Brian G. Weinshenker, Department of Neurology, Mayo Clinic College of Medicine, W8B,Mayo Clinic College of Medicine,200 First St SW ,Rochester MN 55905 USAweinb@mayo.edu
    • Anu Jacob
    Submitted December 04, 2006
  • Occurrence of CNS demyelinating disease in patients with myasthenia gravis
    • Ken Ikeda, Department of Neurology, PL Tokyo Health Care Center, 16-1, Kamiyamacho, Shibuyaku, Tokyo, 150-0047, Japankeni@pl-tokyo-kenkan.gr.jp
    • Yo Araki, and Yasuo Iwasaki.
    Submitted December 04, 2006
  • Occurrence of CNS demyelinating disease in patients with myasthenia gravis
    • Ilya Kister, NYU/Hospital for Joint Diseases, 301 East 17th Sreet, Suite 550, New York, NY 10003ilya.kister@mssm.edu
    • Joseph Herbert, Michael L. Swerdlow, Roberto Bergamaschi, Giovanni Piccolo and Joel Oger
    Submitted December 04, 2006
  • Reply from the Authors
    • Marc Gotkine, Department of Neurology, Hadassah University Hospital, P.O. Box 12000, Jerusalem 91120, Israelmarcgotkine@gmail.com
    • Oded Abramsky
    Submitted December 04, 2006
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