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In cluster headache (CH), autonomic signs are usually reported as ipsilateral to the painful side. However, quantitative studies1 have proven bilateral increase of both lacrimation and nasal secretion during attacks, predominantly on the symptomatic side. Although conjunctival injection also seems bilateral but predominant on the side of the pain,2 no objective estimation of ictal conjunctival injection has been performed.
Therefore, we sought to witness CH attacks and study the pattern of ictal conjunctival injection in both eyes.
Methods.
Over 1 year we studied all consecutive patients who met IHS diagnostic criteria for CH3 and agreed to participate and sign informed consent. All patients had normal neurologic and ophthalmologic examinations. Routine blood and urine analysis and brain MRI examinations were also normal. Patients were asked not to take any medication before the study was performed.
Interictally and during attacks, high quality pictures centered in both eyes were taken under the same conditions of light, magnification, and exposure …
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