March 27, 2007; 68 (13) Article
Inflammatory biomarkers are associated with total brain volume
The Framingham Heart Study
A. L. Jefferson, J. M. Massaro, P. A. Wolf, S. Seshadri, R. Au, R. S. Vasan, M. G. Larson, J. B. Meigs, J. F. Keaney, I. Lipinska, S. Kathiresan, E. J. Benjamin, C. DeCarli
First published March 26, 2007, DOI: https://doi.org/10.1212/01.wnl.0000257815.20548.df
A. L. Jefferson
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
J. M. Massaro
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
P. A. Wolf
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
S. Seshadri
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
R. Au
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
R. S. Vasan
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
M. G. Larson
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
J. B. Meigs
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
J. F. Keaney Jr
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
I. Lipinska
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
S. Kathiresan
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
E. J. Benjamin
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
C. DeCarli
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
Inflammatory biomarkers are associated with total brain volume
The Framingham Heart Study
A. L. Jefferson, J. M. Massaro, P. A. Wolf, S. Seshadri, R. Au, R. S. Vasan, M. G. Larson, J. B. Meigs, J. F. Keaney, I. Lipinska, S. Kathiresan, E. J. Benjamin, C. DeCarli
Neurology Mar 2007, 68 (13) 1032-1038; DOI: 10.1212/01.wnl.0000257815.20548.df
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vol. 68 no. 13 1032-1038
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History:
- First Published March 26, 2007.
Copyright & Usage:
© 2007
Author Disclosures
- A. L. Jefferson, PhD,
- J. M. Massaro, PhD,
- P. A. Wolf, MD,
- S. Seshadri, MD,
- R. Au, PhD,
- R. S. Vasan, MD,
- M. G. Larson, ScD,
- J. B. Meigs, MD, MPH,
- J. F. Keaney Jr, MD,
- I. Lipinska, PhD,
- S. Kathiresan, MD,
- E. J. Benjamin, MD, ScM and
- C. DeCarli, MD
- A. L. Jefferson, PhD,
- J. M. Massaro, PhD,
- P. A. Wolf, MD,
- S. Seshadri, MD,
- R. Au, PhD,
- R. S. Vasan, MD,
- M. G. Larson, ScD,
- J. B. Meigs, MD, MPH,
- J. F. Keaney Jr, MD,
- I. Lipinska, PhD,
- S. Kathiresan, MD,
- E. J. Benjamin, MD, ScM and
- C. DeCarli, MD
- From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
- Address correspondence and reprint requests to Dr. Angela L. Jefferson, Department of Neurology, Boston University School of Medicine, 715 Albany Street, B-7800, Boston, MA 02118; e-mail: angelaj{at}bu.edu
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