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March 27, 2007; 68 (13) Article

Inflammatory biomarkers are associated with total brain volume

The Framingham Heart Study

A. L. Jefferson, J. M. Massaro, P. A. Wolf, S. Seshadri, R. Au, R. S. Vasan, M. G. Larson, J. B. Meigs, J. F. Keaney, I. Lipinska, S. Kathiresan, E. J. Benjamin, C. DeCarli
First published March 26, 2007, DOI: https://doi.org/10.1212/01.wnl.0000257815.20548.df
A. L. Jefferson
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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J. M. Massaro
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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P. A. Wolf
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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S. Seshadri
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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R. Au
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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R. S. Vasan
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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M. G. Larson
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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J. B. Meigs
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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J. F. Keaney Jr
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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I. Lipinska
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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S. Kathiresan
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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E. J. Benjamin
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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C. DeCarli
From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
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Full PDF
Citation
Inflammatory biomarkers are associated with total brain volume
The Framingham Heart Study
A. L. Jefferson, J. M. Massaro, P. A. Wolf, S. Seshadri, R. Au, R. S. Vasan, M. G. Larson, J. B. Meigs, J. F. Keaney, I. Lipinska, S. Kathiresan, E. J. Benjamin, C. DeCarli
Neurology Mar 2007, 68 (13) 1032-1038; DOI: 10.1212/01.wnl.0000257815.20548.df

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Article Information

vol. 68 no. 13 1032-1038
DOI: 
https://doi.org/10.1212/01.wnl.0000257815.20548.df
PubMed: 
17389308

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • First Published March 26, 2007.

Copyright & Usage: 
© 2007

Author Disclosures

    1. A. L. Jefferson, PhD,
    2. J. M. Massaro, PhD,
    3. P. A. Wolf, MD,
    4. S. Seshadri, MD,
    5. R. Au, PhD,
    6. R. S. Vasan, MD,
    7. M. G. Larson, ScD,
    8. J. B. Meigs, MD, MPH,
    9. J. F. Keaney Jr, MD,
    10. I. Lipinska, PhD,
    11. S. Kathiresan, MD,
    12. E. J. Benjamin, MD, ScM and
    13. C. DeCarli, MD
  1. A. L. Jefferson, PhD,
  2. J. M. Massaro, PhD,
  3. P. A. Wolf, MD,
  4. S. Seshadri, MD,
  5. R. Au, PhD,
  6. R. S. Vasan, MD,
  7. M. G. Larson, ScD,
  8. J. B. Meigs, MD, MPH,
  9. J. F. Keaney Jr, MD,
  10. I. Lipinska, PhD,
  11. S. Kathiresan, MD,
  12. E. J. Benjamin, MD, ScM and
  13. C. DeCarli, MD
  1. From the Departments of Neurology (A.L.J., P.A.W., S.S., R.A.) and Preventive Medicine (R.S.V., E.J.B.), Whitaker Cardiovascular Institute (R.S.V., J.F.K., I.L., E.J.B.), Boston University School of Medicine; National Heart, Lung and Blood Institute's Framingham Heart Study (J.M.M., P.A.W., S.S., R.A., R.S.V., M.G.L., S.K., E.J.B.), Framingham, MA; Department of Biostatistics (J.M.M.), Boston University School of Public Health; Department of Mathematics and Statistics (M.G.L.), Boston University; General Medical Division (J.B.M.) and Cardiovascular Disease Prevention Center (S.K.), Massachusetts General Hospital and Harvard Medical School, Boston, MA; and Department of Neurology, Center for Neuroscience, and Imaging of Dementia and Aging Laboratory (C.D.), University of California at Davis.
  1. Address correspondence and reprint requests to Dr. Angela L. Jefferson, Department of Neurology, Boston University School of Medicine, 715 Albany Street, B-7800, Boston, MA 02118; e-mail: angelaj{at}bu.edu
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