Altered arterial function in migraine of recent onset
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Abstract
Objective: Migraine is associated with cardiovascular disorders but the underlying mechanisms are unknown. Arterial structure and function are important determinants of cardiovascular morbidity and mortality. The aim of the present study was to assess arterial properties in patients with migraine of recent onset.
Methods: In a cross-sectional study, structural and functional arterial properties were assessed using ultrasound and applanation tonometry in 50 patients with a history of migraine >1 and <6 years during a headache-free interval and 50 age- and gender-matched subjects without a history of migraine.
Results: Brachial artery diameter (4.82 ± 0.93 mm vs 5.39 ± 0.89 mm, p = 0.01) and compliance (0.30 ± 0.17 mm2/kPa vs 0.37 ± 0.19 mm2/kPa, p = 0.02) were decreased in migraine patients compared with controls. Femoral artery compliance was decreased in migraine patients (1.19 ± 0.55 mm2/kPa vs 1.42 ± 0.59 mm2/kPa, p = 0.04). Carotid arterial wall properties were similar between groups. Aortic augmentation index was increased in migraine patients (4 ± 10% vs −1 ± 10%, adjusted p = 0.04). Flow-mediated vasodilation of the brachial artery (normalized to peak shear rate) was decreased in patients with migraine (29 ± 15 vs 37 ± 15 10−3%. sec, p = 0.006).
Conclusion: Functional arterial properties are altered in patients with migraine of recent onset.
Footnotes
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Editorial, see page 1555
This article was previously published in electronic format as an Expedited E-Pub at www.neurology.org.
Supported by a grant from the Research Foundation—Flanders (F.W.O.—Vlaanderen). Floris Vanmolkot was a Junior Research Fellow of the F.W.O.—Vlaanderen.
Disclosure: The authors report no conflicts of interest.
Received September 8, 2006. Accepted in final form February 5, 2007.
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Letters: Rapid online correspondence
- Altered arterial function in migraine of recent onset
- Steven R Brenner, Departments of Neurology at the St. Louis VA Medical Center and St. Louis University Medical Center, Dept's Neurology, JC 127, St. Louis VA Medical Center, 915 North Grand, St. Louis, Mo 16106SBren20979@aol.com
- None
Submitted August 02, 2007 - Altered arterial function in migraine of recent onset
- David S. Summers, Retired neurologist (U. of UT Medical Center, 1972-76), 1520 Pasadena Dr. Erie, PA 16505dssmd@earthlink.net
- (no other authors)
Submitted August 02, 2007 - Reply from the authors
- Jan N de Hoon, Center for Clinical Pharmacology, University Hospital Gasthuisberg (K.U.Leuven), Herestraat 49, 3000 Leuven, Belgiumjan.dehoon@uz.kuleuven.ac.be
- Floris Vanmolkot
Submitted August 02, 2007
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