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June 05, 2007; 68 (23) NeuroImages

Silent T2* cerebral microbleeds

A potential new imaging clue in infective endocarditis

I. Klein, B. Iung, M. Wolff, E. Brochet, P. Longuet, J.-P Laissy, X. Duval
First published June 4, 2007, DOI: https://doi.org/10.1212/01.wnl.0000266965.04112.bc
I. Klein
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B. Iung
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M. Wolff
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E. Brochet
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P. Longuet
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J.-P Laissy
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X. Duval
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Citation
Silent T2* cerebral microbleeds
A potential new imaging clue in infective endocarditis
I. Klein, B. Iung, M. Wolff, E. Brochet, P. Longuet, J.-P Laissy, X. Duval
Neurology Jun 2007, 68 (23) 2043; DOI: 10.1212/01.wnl.0000266965.04112.bc

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In an IV drug–addicted, neurologically asymptomatic, 40-year-old man with definite infective endocarditis (IE), T2* MRI revealed numerous cerebral microhemorrhages known as microbleeds. The anatomic location of one microbleed matched with that of a nonruptured mycotic aneurysm (figure 1, A to D). Moreover, T2* follow-up imaging before cardiac surgery showed that the number of microbleeds had asymptomatically increased twofold, despite antibiotherapy (figure 2, A and B). Such rapid variation may suggest an active microvascular underlying process causally linked to IE. Furthermore, the microbleeds appeared qualitatively and anatomically different from those reported in other causes of microhemorrhages, e.g., amyloid angiopathy, chronic hypertension, or multiple cavernoma syndromes. T2* MRI appears as a promising noninvasive method to target patients at risk for developing intracranial bleeding or mycotic aneurysm in IE, as has been suggested previously.1

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Figure 1 T2* brain MRI

T2* brain MRI (A) showed corticomeningeal small black dots related to microbleeds. At the corresponding site of a left frontal microbleed (white arrow), axial and sagittal MRA views (B and C) suggested the presence of a fusiform mycotic aneurysm of which the arterial origin was confirmed by cerebral angiography (D).

Figure2
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Figure 2 Initial and follow-up T2* MRI

Initial (A) and follow-up (B) T2* MRI showed an increase of the microbleeds at the gray-white matter junction differentially located from acute ischemic lesions depicted as hyperintensities on diffusion MRI (C).

Footnotes

  • Disclosure: The authors report no conflicts of interest.

REFERENCE

  1. 1.↵
    Subramaniam S, Puetz V, Dzialowski I, Barber BA. Cerebral microhemorrhages in a patient with mycotic aneurysm: relevance of T2-GRE imaging in SBE. Neurology 2006;67:1697.
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Disputes & Debates: Rapid online correspondence

  • Silent T2* cerebral microbleeds: A potential new imaging clue in infective endocarditis
    • R. N. Kaveer Nandigam, MD, Research Fellow, Neurology, Massachusetts General Hospital, MGH Stroke Center, 175 Cambridge St, Suite 300, Boston, MA 02114rnandigam@partners.org
    Submitted October 03, 2007
  • Reply from the authors
    • Isabelle Klein, Bichat University Hospital, APHP, 46 rue Henri Huchard 75018 Parisisabelle.klein@bch.aphp.fr
    • Bernard Iung, Michel Wolff,Eric Brochet,Pascale Longuet, Jean-Pierre Laissy, Xavier Duval
    Submitted October 03, 2007
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