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MULTIPLE SCLEROSIS AS A NEURONAL DISEASE
edited by Stephen Waxman, MD, 496 pp., Elsevier Academic Press, 2005, 2005, $170
Multiple sclerosis (MS) is no longer regarded as just a disorder of demyelination. During the last decade, the emphasis of pathogenesis and pathophysiology of this disorder has changed to include not only myelin, but also the axon. More recently, cerebral cortical plaques have been rediscovered in MS, implicating a role for degeneration also of the neuronal perikaryon. This awareness has sparked an interest in the possibility of MS being regarded as not just a disorder of the white matter (axons and myelin) but also of the gray matter. In …
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