Treatment strategies across the multiple sclerosis lifespan
Citation Manager Formats
Make Comment
See Comments

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Multiple sclerosis (MS) is a chronic disease of the CNS and was described as early as the fourteenth century. Early attempts at treatment included primarily symptomatic therapies, but in the 1960s and 1970s the focus of research shifted to disease-modifying therapy (DMT). The first of these therapies to be approved by the FDA was interferon-beta1b (IFN-β1b) in 1993. Since that time there has been a significant expansion of research aimed at modifying the MS disease process.
The present-day management of MS patients requires an understanding of an evolving therapeutic paradigm. In this paradigm, the efficacy, mechanisms of action, and effects of the available therapies intersect and are relevant to clinical practice. The efficacy of four of the DMTs—IFN-β1b SC, IFN-β1a SC and IM formulations, and glatiramer acetate SC—is well established, with some studies having over a decade of follow-up data.1–3 The practicing clinician should understand the differences in the administration and mechanisms of action of the DMTs and how these differences impact the clinical effects.4–6 The clinical effect of neutralizing antibodies (NAbs) and the risk for serious adverse effects of some DMTs (e.g., progressive multifocal leukoencephalopathy with natalizumab) are also factors that must be considered in …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)
Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here
Purchase
Individual access to articles is available through the Add to Cart option on the article page. Access for 1 day (from the computer you are currently using) is US$ 39.00. Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means. The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use. Distributing copies (electronic or otherwise) of the article is not allowed.
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Dr. Ann Yeh and Dr. Daniela Castillo Villagrán
► Watch
Related Articles
- No related articles found.
Alert Me
Recommended articles
-
Special Article
Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosisReport of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of NeurologyAlexander Rae-Grant, Gregory S. Day, Ruth Ann Marrie et al.Neurology, April 23, 2018 -
Views & Reviews
Comment on 2018 American Academy of Neurology guidelines on disease-modifying therapies in MSJohn R. Corboy, Brian G. Weinshenker, Dean M. Wingerchuk et al.Neurology, April 23, 2018 -
Articles
Evidence-based medicine and clinical trialsPatricia K. Coyle et al.Neurology, June 11, 2007 -
Articles
Treatment of pediatric multiple sclerosis and variantsD. Pohl, E. Waubant, B. Banwell et al.Neurology, April 16, 2007