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January 15, 2008; 70 (3) Articles

Basal ganglia involvement in temporal lobe epilepsy

A functional and morphologic study

V. Bouilleret, F. Semah, F. Chassoux, M. Mantzaridez, A. Biraben, R. Trebossen, M. -J. Ribeiro
First published January 14, 2008, DOI: https://doi.org/10.1212/01.wnl.0000297514.47695.48
V. Bouilleret
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F. Semah
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F. Chassoux
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M. Mantzaridez
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A. Biraben
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R. Trebossen
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M. -J. Ribeiro
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Citation
Basal ganglia involvement in temporal lobe epilepsy
A functional and morphologic study
V. Bouilleret, F. Semah, F. Chassoux, M. Mantzaridez, A. Biraben, R. Trebossen, M. -J. Ribeiro
Neurology Jan 2008, 70 (3) 177-184; DOI: 10.1212/01.wnl.0000297514.47695.48

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Abstract

Objectives: A decrease of [18F]fluoro-l-dopa uptake in basal ganglia was recently reported in medically refractory epilepsy. The purpose of this study was to assess the involvement of dopaminergic neurotransmission in refractory temporal lobe epilepsy (TLE) and its relationship to glucose metabolism and morphologic changes.

Methods: Twelve TLE patients were studied using [18F]fluorodeoxyglucose PET, [18F]fluoro-l-dopa PET, and MRI and compared with healthy control volunteers. Morphologic cerebral changes were assessed using voxel-based morphometry. Student t test statistical maps of functional and morphologic differences between patients and controls were obtained using a general linear model.

Results: In TLE patients, [18F]fluoro-l-dopa uptake was reduced to the same extent in caudate and putamen in both cerebral hemispheres as well as in the substantia nigra (SN). These dopaminergic functional alterations occurred without any glucose metabolism changes in these areas. The only mild morphologic abnormality was found in striatal regions without any changes in the SN.

Conclusion: The present study provides support for dopaminergic neurotransmission involvement in temporal lobe epilepsy. The discrepancies between gray matter volume atrophy and the pattern of [18F]fluoro-l-dopa suggest that basal ganglia involvement is not related to structural subcortical abnormalities. A functional decrease can be ruled out because there was no change of the glycolytic pathway metabolism in these areas.

Glossary

AED=
antiepileptic drug;
BG=
basal ganglia;
CBZ=
carbamazepine;
CLB=
clobazam;
DNET=
dysembryoplastic neuroepitheliale tumor;
FC=
febrile convulsion; [18F]FDG ;
FWHM=
full-width at half-maximum;
GBP=
gabapentin;
GMV=
gray matter volume;
GVB=
vigabatrin;
LHS=
left hippocampal sclerosis;
LTG=
lamotrigine;
OXC=
oxcarbazepine;
PB=
phenobarbital;
ROI=
region of interest;
SN=
substantia nigra;
TLE=
temporal lobe epilepsy;
TPM=
topiramate;
VPA=
sodium valproate;
WMV=
white matter volume.
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Disputes & Debates: Rapid online correspondence

  • Basal ganglia involvement in temporal lobe epilepsy: A functional and morphologic study
    • David S. Goldstein, Clinical Neurocardiology Section, CNP, DIR, NINDS, NIH, 10 Center Drive MSC-1620, Bethesda, MD 20892-1620goldsteind@ninds.nih.gov
    Submitted April 08, 2008
  • Reply from the authors
    • Franck Semah, Service Hospitalier Frédéric Joliot, I2BM/DSV, 4, Place du General Leclerc, 91401 Orsay Cedex, Francemaria-joao.ribeiro@cea.fr
    • Viviane Bouilleret and Maria-Joao Ribeiro
    Submitted April 08, 2008
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