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January 15, 2008; 70 (3) Articles

APOE ε4 allele is associated with cognitive impairment in patients with multiple sclerosis

J. Shi, C. B. Zhao, T. L. Vollmer, T. M. Tyry, S. M. Kuniyoshi
First published April 25, 2007, DOI: https://doi.org/10.1212/01.wnl.0000264004.62612.44
J. Shi
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C. B. Zhao
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T. L. Vollmer
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T. M. Tyry
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S. M. Kuniyoshi
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Citation
APOE ε4 allele is associated with cognitive impairment in patients with multiple sclerosis
J. Shi, C. B. Zhao, T. L. Vollmer, T. M. Tyry, S. M. Kuniyoshi
Neurology Jan 2008, 70 (3) 185-190; DOI: 10.1212/01.wnl.0000264004.62612.44

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Abstract

Background: The role of apolipoprotein E (APOE) polymorphism has been well recognized in other cognitive neurodegenerative disorders, such as Alzheimer disease. Its role in multiple sclerosis (MS) is less clear, though studies indicate that 40% to 60% of patients with MS have evidence of cognitive impairment.

Objective: To determine whether there is an association between APOE ε4 and cognitive deficits in MS.

Methods: We performed a standardized battery of neuropsychological tests investigating the four cognitive domains commonly impaired in MS and assessed the association of the presence of APOE ε4 with cognition in MS.

Results: A strong association was found between the presence of APOE ε4 and cognitive deficits in patients with MS, particularly in the domains of learning and memory. This association was strongest in our youngest cohort (age 31 to 40) of patients with MS.

Conclusions: APOE ε4 is significantly associated with cognitive impairment in patients with multiple sclerosis (MS). However, the modest effects do not justify APOE genotyping of patients with MS in clinical practice.

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Letters: Rapid online correspondence

  • APOE 4 allele is associated with cognitive impairment in patients with multiple sclerosis
    • Alan A. Mazurek, Mt. Sinai Medical Center, 371 Merrick Road Suite 401 Rockville Centre,NY 11570DRAAM@aol.com
    Submitted March 13, 2008
  • Reply from the authors
    • Jiong Shi, Barrow Neurological Institute, 500 W. Thomas Road, Suite 720, Phoenix, AZ 85013jiong.shi@chw.edu
    Submitted March 13, 2008
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