SENSITIVITY AND SPECIFICITY OF THE ASSOCIATION BETWEEN CATAMENIAL SEIZURE PATTERNS AND OVULATION
Citation Manager Formats
Make Comment
See Comments

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Some ovarian steroids such as estradiol (E)1,2 and progesterone (P)3,4 have neuroactive properties that can affect neuronal excitability. Cyclic changes in the serum concentrations of these steroids in relation to the menstrual cycle may induce variation in seizure frequency that has been termed catamenial epilepsy.5,6 There is statistical evidence to support the existence of at least three patterns: 1) perimenstrual (C1: day −3 to 3), 2) periovulatory (C2: day 10 to −13) in ovulatory cycles, and 3) luteal (C3: day 10 to 3) in anovulatory cycles. Day 1 refers to the day of onset of menstrual flow and Day −14 is presumed to represent the day of ovulation in ovulatory cycles.5,6 There are also mathematically based levels of seizure exacerbation for designation of catamenial epilepsy for each of these patterns. Although different patterns of catamenial exacerbation have been observed with ovulatory and anovulatory cycles, their sensitivity and specificity remain to be established.5,6
Methods.
The subjects were 100 women with localization-related epilepsy, 13 to 45 years of age, who had intractable seizures, i.e., persistence of two or more monthly seizures despite documented trials of at least two antiepileptic drugs with therapeutic range levels. The subjects were participating in the baseline phase of a clinical trial of progesterone therapy. The women recorded …
AAN Members: Sign in with your AAN member credentials (e-mail or 6-digit Member ID number)
Non-AAN Member subscribers: Sign in with subscriber credentials
Log in using your username and password
Purchase access
AAN members must change their passwords on the AAN site
For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)
Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here
Purchase
Individual access to articles is available through the Add to Cart option on the article page.
Access for 1 day (from the computer you are currently using) is US$ 39.00.
Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.
The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use. Distributing copies (electronic or otherwise) of the article is not allowed.
Disputes & Debates: Rapid online correspondence
NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.
- Stay timely. Submit only on articles published within the last 8 weeks.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- 200 words maximum.
- 5 references maximum. Reference 1 must be the article on which you are commenting.
- 5 authors maximum. Exception: replies can include all original authors of the article.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Related Articles
- No related articles found.