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We have discovered that rhinorrhea is a common problem in our patients with Parkinson disease (PD) but we have found no published reference to it. To confirm our clinical suspicion we conducted a case-control study.
Using an IRB approved protocol, we enrolled consecutive patients with PD, receiving neurologic care at our Movement Disorders Clinic. Each person without PD over age 50 who accompanied the patient to the visit was asked to serve as a control. No one declined to participate. Patients and controls were asked whether they had a runny nose unrelated to a cold or allergy, whether it increased with eating, and if the problem began before or after the onset of PD. Participants were also asked whether they had an impaired sense of smell. If rhinorrhea began around the same time as PD symptoms, we recorded it as occurring after the onset of motor symptoms. We did not formally define criteria for rhinorrhea. We did not test olfaction and we did not attempt to associate particular foods with rhinorrhea.
The diagnosis of PD was made using UK Brain Bank Criteria,1 and patients had to be able to answer questions reliably. Duration …
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