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July 01, 2008; 71 (1) Articles

Economic cost of Guillain-Barré syndrome in the United States

P. D. Frenzen
First published June 30, 2008, DOI: https://doi.org/10.1212/01.wnl.0000316393.54258.d1
P. D. Frenzen
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Economic cost of Guillain-Barré syndrome in the United States
P. D. Frenzen
Neurology Jul 2008, 71 (1) 21-27; DOI: 10.1212/01.wnl.0000316393.54258.d1

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Abstract

Objective: This study estimated the annual economic cost of Guillain-Barré syndrome (GBS) in the United States in 2004, including the direct costs of medical care and the indirect costs due to lost productivity and premature death.

Methods: The cost-of-illness method was used to determine the costs of medical care and lost productivity, and a modified value of a statistical life approach was used to determine the cost of premature deaths. Data were obtained from the Nationwide Inpatient Sample, the Medical Expenditure Panel Survey, the Compressed Mortality File, a telephone survey of 180 adult patients with GBS, and other sources.

Results: The estimated annual cost of GBS was $1.7 billion (95% CI, $1.6 to 1.9 billion), including $0.2 billion (14%) in direct medical costs and $1.5 billion (86%) in indirect costs. Most of the medical costs were for community hospital admissions. Most of the indirect costs were due to premature deaths. The mean cost per patient with GBS was $318,966 (95% CI, $278,378 to 359,554).

Conclusions: The economic cost of Guillain-Barré syndrome (GBS) was substantial, and largely due to disability and death. The cost estimate summarizes the lifetime health burden due to GBS in monetary terms, and provides some of the information needed to assess the cost-effectiveness of health measures that affect GBS.

Glossary

CPI=
Consumer Price Index;
DALY=
disability-adjusted life years;
DRG=
Diagnosis Related Group;
FDA=
Food and Drug Administration;
GBS=
Guillain-Barré syndrome;
HCUP=
Healthcare Cost and Utilization Project;
ICD-9-CM=
International Classification of Diseases, 9th Revision, Clinical Modification;
IRF=
inpatient rehabilitation facility;
LOS=
length of stay;
LTCH=
long-term care hospital;
MEPS=
Medical Expenditure Panel Survey;
NIS=
Nationwide Inpatient Sample;
PE=
plasma exchange;
SNF=
skilled nursing facility.
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Disputes & Debates: Rapid online correspondence

  • Economic cost of Guillain-Barré syndrome in the United States
    • Gregory L. Pittman, #56, 3900 Kresge Way, Louisville, KY 40207gpittman@nsapsc.com
    Submitted August 29, 2008
  • Reply from the author
    • P.D. Frenzen, Economic Research Service, USDA, 1800 M Street, N.W., Washington DC 20036pfrenzen@ers.usda.gov
    Submitted August 29, 2008
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