Multifocal neuropathy associated with West Nile virus infection
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A 51-year-old man developed severe, subacute onset right facial weakness and flaccid, hyporeflexic right upper limb weakness several days following West Nile virus infection. Electrophysiologic and radiographic studies confirmed severe but incomplete right facial and brachial plexus neuropathies (figure). There were no clinical or laboratory findings to suggest encephalitis or myelitis. For additional details regarding his diagnosis, see appendix e-1 on the Neurology® Web site at www.neurology.org.
Figure Coronal short tau inversion recovery MRI demonstrating thickening and T2 signal prolongation in the right (symptomatic) brachial plexus (broad arrow)
The contralateral (asymptomatic) brachial plexus (narrow yellow arrow) appears normal.
Since its arrival in North America, West Nile virus infection has been associated with a number of neuromuscular manifestations,1 such as a poliomyelitis-like motor neuronopathy, Guillain-Barré syndrome, isolated brachial plexus neuropathy, and now multifocal neuropathy. MRI continues to emerge as a useful tool in the evaluation of neuromuscular disorders.2
1. Jeha LE, Sila CA, Lederman RJ, Prayson RA, Isada CM, Gordon SM. West Nile virus infection: a new acute paralytic illness. Neurology 2003;61:55–59.OpenUrlAbstract/FREE Full Text
2. Zhou L, Yousem DM, Chaudhry V. Role of magnetic resonance neurography in brachial plexus lesions. Muscle Nerve 2004;30:305–309.OpenUrlPubMed
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Supplemental data at www.neurology.org
Disclosure: Dr. Jones has received federal grant support. Dr. Sumner has nothing to disclose.
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