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To the Editor:
We read the article by Ahn et al. with great interest.1
As part of a similar study, we recently tested 403 patients with a diagnosis of Parkinson disease (PD) (234 men, mean age at onset: 48.0 ± 11.6 years) for gene dosage changes of SNCA by quantitative duplex PCR (n = 292) or MLPA (n = 111).2 We detected one SNCA duplication in a 38-year-old woman with a 2-year history of parkinsonism (1/403; 0.25%; figure e-1 on the Neurology® Web site at www.neurology.org), which is comparable to the number reported by Ahn et al. in a Korean PD population (3/906 = 0.3%).
Neurologic examination of our patient revealed generalized bradykinesia, rigidity predominantly of her right limbs, and mild postural instability but no rest tremor (UPDRS-III score: 32/108). We also …
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